Tyrosine-protein kinase CSK

BE0001356ProteinHumansCSK

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. It is acted on by 4 drugs in DrugBank.

Gene name
CSK
UniProtKB entry
P41240Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
450 residues · 50,704 Da
Also known as
2.7.10.4 · C-Src kinase · Protein-tyrosine kinase CYL

Resolves to

Protein
UniProtP41240UniProt nameCSK_HUMAN
Gene
HGNCHGNC:2444NCBI Gene1445GenBank30315GeneCardsCSK
Pharmacology
IUPHAR/GtoPdb1994KEGGhsa:1445
Structure
PDB1BYGPDB1CSKPDB3D7T
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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26GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein kinase CSK, how selective are they, and which programs against it are still in active trials?

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