Isoleucine--tRNA ligase

BE0001372ProteinThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)ileS

Catalyzes the attachment of isoleucine to tRNA(Ile). It is acted on by 1 drug in DrugBank.

Gene name
ileS
UniProtKB entry
P56690Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,043 residues · 119,246 Da
Also known as
6.1.1.5 · IleRS · Isoleucyl-tRNA synthetase

Resolves to

Protein
UniProtP56690UniProt nameSYI_THET8
Gene
NCBI Gene3168241GenBank55772449
Pharmacology
KEGGttj:TTHA1067
Structure
PDB1ILEPDB1JZQPDB1JZS
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Isoleucine--tRNA ligase, and which indications are they being tested in?

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