MAP kinase-activated protein kinase 2

BE0001373ProteinHumansMAPKAPK2

Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. It is acted on by 10 drugs in DrugBank.

Gene name
MAPKAPK2
UniProtKB entry
P49137Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
400 residues · 45,567 Da
Also known as
2.7.11.1 · MAPK-activated protein kinase 2 · MAPKAP kinase 2 · MAPKAP-K2 · MAPKAPK-2

Resolves to

Protein
UniProtP49137UniProt nameMAPK2_HUMAN
Gene
HGNCHGNC:6887NCBI Gene9261GenBank530090GeneCardsMAPKAPK2
Pharmacology
IUPHAR/GtoPdb2094KEGGhsa:9261
Structure
PDB1KWPPDB1NXKPDB1NY3
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
2Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
4GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
55+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on MAP kinase-activated protein kinase 2, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In