Peptidyl-prolyl cis-trans isomerase F, mitochondrial

BE0001399ProteinHumansPPIF

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). It is acted on by 6 drugs in DrugBank.

Gene name
PPIF
UniProtKB entry
P30405Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
207 residues · 22,040 Da
Also known as
5.2.1.8 · Cyclophilin D · Cyclophilin F · CyP-D · CyP-M

Resolves to

Protein
UniProtP30405UniProt namePPIF_HUMAN
Gene
HGNCHGNC:9259NCBI Gene10105GenBank181274GeneCardsPPIF
Pharmacology
KEGGhsa:10105
Structure
PDB2BITPDB2BIUPDB2Z6W
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peptidyl-prolyl cis-trans isomerase F, mitochondrial, how selective are they, and which programs against it are still in active trials?

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