9-(N-methyl-L-isoleucine)-cyclosporin A

DB13068InvestigationalSmall molecule

9-(N-methyl-L-isoleucine)-cyclosporin A (NIM811) has been used in trials studying the treatment of Chronic Hepatitis C Genotype-1 Relapse.

Mechanism: Pharmacologically active on Peptidyl-prolyl cis-trans isomerase A and Peptidyl-prolyl cis-trans isomerase F, mitochondrial
Curator reviewed
Formula / weight: C₆₂H₁₁₁N₁₁O₁₂ · 1202.635 g/mol (avg)
Code names: NIM811

Resolves to

Compound

UNII96262S4I14CAS143205-42-9ChEMBLCHEMBL1688529PubChem6473876

Structure

InChIKeyRPJPZDVUUKWPGT-FOIHOXPVSA-NSMILES

CC[C@H](C)[C@@H]1N(C)C(=O)CN(C)C(=O)[C@H](CC)NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC1=O)C(C)C

Targets

P62937PPIAP30405PPIF

What you can answer from here — as of July 07, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

363Drug interactionsStructured to mechanism, not free text

1Clinical trialPhase, status and sponsor resolved per trial

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with 9-(N-methyl-L-isoleucine)-cyclosporin A, and which of those have an active Phase 3 trial?

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