2-hydroxymuconate tautomerase

BE0001410ProteinPseudomonas putidaxylH

Catalyzes the ketonization of 2-hydroxymuconate stereoselectively to yield 2-oxo-3-hexenedioate. It is acted on by 1 drug in DrugBank.

Gene name
xylH
UniProtKB entry
Q01468Swiss-Prot
Residues / weight
63 residues · 6,942 Da
Also known as
4-OT · 4-oxalocrotonate tautomerase · 5.3.2.6

Resolves to

Protein
UniProtQ01468UniProt name4OT1_PSEPU
Gene
NCBI Gene1218749GenBank151717
Pharmacology
KEGGpg:1218749
Structure
PDB1BJPPDB2FM7PDB4OTA
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 2-hydroxymuconate tautomerase, and which indications are they being tested in?

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