Thymidylate synthase

BE0001438ProteinEscherichia coli (strain K12)thyA

Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product (PubMed:2223754, PubMed:3286637, PubMed:9826509). It is acted on by 24 drugs in DrugBank.

Gene name
thyA
UniProtKB entry
P0A884Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
264 residues · 30,479 Da
Also known as
2.1.1.45 · TS

Resolves to

Protein
UniProtP0A884UniProt nameTYSY_ECOLI
Gene
NCBI Gene949035GenBank147987
Pharmacology
KEGGecj:JW2795
Structure
PDB1AIQPDB1AJMPDB1AN5
Drugs

What you can answer from here — as of September 07, 2019

24DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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51+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Thymidylate synthase, how selective are they, and which programs against it are still in active trials?

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