Type II methyltransferase M.RsrI

BE0001456ProteinRhodobacter sphaeroidesrsrIM

A beta subtype methylase, recognizes the double-stranded sequence 5'-GAATTC-3', methylates A-3 on both strands, and protects the DNA from cleavage by the RsrI endonuclease. It is acted on by 3 drugs in DrugBank.

Gene name
rsrIM
UniProtKB entry
P14751Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
319 residues · 35,655 Da
Also known as
2.1.1.72 · Adenine-specific methyltransferase RsrI · M.RsrI · Modification methylase RsrI

Resolves to

Protein
UniProtP14751UniProt nameMTR1_CERSP
Gene
GenBank46455
Structure
PDB1EG2PDB1NW5PDB1NW6
Drugs

What you can answer from here — as of May 03, 2025

3DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Type II methyltransferase M.RsrI, and which indications are they being tested in?

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