Fumarate reductase (cytochrome)

BE0001487ProteinShewanella oneidensis (strain MR-1)fccA

Flavocytochrome that catalyzes the reduction of fumarate to succinate (PubMed:12196158, PubMed:12899636, PubMed:22458729). It is acted on by 3 drugs in DrugBank.

Gene name
fccA
UniProtKB entry
P83223Swiss-Prot
Cellular location
Periplasm
Residues / weight
596 residues · 62,447 Da
Also known as
1.3.2.4 · 1.3.5.4 · Fcc3 · FL cyt · Flavocytochrome c

Resolves to

Protein
UniProtP83223UniProt nameFCCA_SHEON
Gene
NCBI Gene1168814GenBank24346572
Pharmacology
KEGGson:SO_0970
Structure
PDB1D4CPDB1D4DPDB1D4E
Drugs

What you can answer from here — as of May 03, 2025

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Fumarate reductase (cytochrome), how selective are they, and which programs against it are still in active trials?

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