Fumarate reductase flavoprotein subunit
Details
- Name
- Fumarate reductase flavoprotein subunit
- Kind
- protein
- Synonyms
- 1.3.5.4
- FL cyt
- Flavocytochrome c
- Gene Name
- Not Available
- UniProtKB Entry
- P83223Swiss-Prot
- Organism
- Shewanella oneidensis (strain MR-1)
- NCBI Taxonomy ID
- 211586
- Amino acid sequence
>lcl|BSEQ0016447|Fumarate reductase flavoprotein subunit MFTRKIQKTALAMLISGAMAGTAYAAPEVLADFHGEMGGCDSCHVSDKGGVTNDNLTHEN GQCVSCHGDLKELAAAAPKDKVSPHKSHLIGEIACTSCHKGHEKSVAYCDACHSFGFDMP FGGKWERKFVPVDADKAAQDKAIAAGVKETTDVVIIGSGGAGLAAAVSARDAGAKVILLE KEPIPGGNTKLAAGGMNAAETKPQAKLGIEDKKQIMIDDTMKGGRNINDPELVKVLANNS SDSIDWLTSMGADMTDVGRMGGASVNRSHRPTGGAGVGAHVAQVLWDNAVKRGTDIRLNS RVVRILEDASGKVTGVLVKGEYTGYYVIKADAVVIAAGGFAKNNERVSKYDPKLKGFKAT NHPGATGDGLDVALQAGAATRDLEYIQAHPTYSPAGGVMITEAVRGNGAIVVNREGNRFM NEITTRDKASAAILQQKGESAYLVFDDSIRKSLKAIEGYVHLNIVKEGKTIEELAKQIDV PAAELAKTVTAYNGFVKSGKDAQFERPDLPRELVVAPFYALEIAPAVHHTMGGLVIDTKA EVKSEKTGKPITGLYAAGEVTGGVHGANRLGGNAISDIVTYGRIAGASAAKFAKDN
- Number of residues
- 596
- Molecular Weight
- 62447.475
- Theoretical pI
- 7.64
- GO Classification
- Functionsmetal ion binding / succinate dehydrogenase activityComponentsperiplasmic space
- General Function
- Succinate dehydrogenase activity
- Specific Function
- Catalyzes fumarate reduction using artificial electron donors such as methyl viologen. The physiological reductant is unknown, but evidence indicates that flavocytochrome c participates in electron transfer from formate to fumarate and possibly also to trimethylamine oxide (TMAO). This enzyme is essentially unidirectional (By similarity).
- Pfam Domain Function
- Not Available
- Signal Regions
- 1-25
- Transmembrane Regions
- Not Available
- Cellular Location
- Periplasm
- Gene sequence
>lcl|BSEQ0016448|Fumarate reductase flavoprotein subunit ATGTTCACAAGAAAGATTCAAAAAACAGCACTAGCCATGCTGATCTCTGGCGCAATGGCA GGCACAGCCTATGCCGCTCCAGAAGTACTAGCCGATTTTCACGGTGAAATGGGTGGCTGC GATAGCTGCCACGTATCAGACAAAGGTGGCGTGACTAACGACAACCTGACCCATGAGAAT GGCCAATGTGTTAGCTGCCACGGTGACTTAAAAGAACTGGCTGCAGCAGCGCCTAAAGAT AAAGTTTCTCCGCACAAATCTCACTTAATTGGTGAAATCGCTTGTACGAGCTGCCACAAA GGCCACGAAAAATCAGTAGCTTATTGTGATGCTTGCCATAGCTTCGGCTTCGATATGCCA TTTGGTGGCAAGTGGGAACGTAAGTTTGTACCTGTTGATGCAGACAAAGCAGCACAAGAT AAAGCCATTGCTGCTGGTGTGAAAGAAACCACAGACGTTGTAATTATCGGCTCTGGTGGT GCTGGTCTTGCCGCTGCCGTATCTGCCCGTGATGCTGGCGCGAAAGTGATTCTGTTAGAA AAAGAACCTATCCCAGGTGGTAACACTAAACTGGCTGCCGGTGGTATGAACGCCGCAGAA ACTAAGCCACAGGCTAAGTTAGGTATCGAAGATAAGAAACAAATCATGATCGACGACACT ATGAAAGGTGGCCGCAACATCAACGATCCTGAATTAGTTAAAGTACTGGCTAACAACTCT TCAGACTCAATCGATTGGTTAACCTCTATGGGTGCCGACATGACTGACGTGGGTCGTATG GGTGGCGCGAGCGTTAACCGTAGTCACCGTCCAACCGGTGGTGCAGGTGTTGGTGCTCAC GTAGCACAAGTGCTGTGGGACAACGCCGTTAAGCGTGGTACTGATATTCGCTTAAACAGC CGCGTTGTGCGCATCCTTGAAGATGCAAGCGGTAAAGTGACCGGCGTTTTAGTGAAAGGT GAATACACAGGTTACTATGTGATCAAAGCCGATGCAGTAGTCATTGCAGCAGGTGGTTTT GCGAAAAACAACGAACGTGTTTCTAAATACGATCCTAAGTTAAAAGGCTTTAAAGCGACC AACCACCCAGGTGCGACGGGTGACGGCTTAGACGTAGCTCTACAAGCGGGCGCAGCAACA CGTGACTTAGAATACATCCAAGCTCACCCAACTTACTCTCCAGCGGGTGGCGTGATGATC ACCGAGGCAGTACGTGGTAACGGTGCAATCGTGGTGAACCGTGAAGGTAATCGTTTTATG AACGAAATCACCACCCGTGATAAAGCGTCTGCGGCGATTCTGCAACAAAAAGGTGAAAGC GCTTACCTAGTATTCGATGACTCTATCCGTAAGAGCTTGAAGGCCATCGAAGGTTATGTT CACCTGAACATTGTAAAAGAAGGTAAAACCATCGAAGAGTTAGCGAAACAAATCGATGTA CCTGCAGCTGAATTGGCAAAAACAGTAACAGCCTACAACGGTTTCGTTAAATCAGGTAAA GATGCTCAATTTGAACGTCCTGATTTACCACGTGAATTAGTGGTAGCTCCTTTCTACGCC TTAGAAATTGCACCAGCGGTTCACCACACTATGGGTGGTCTGGTGATTGATACTAAAGCC GAAGTGAAGAGTGAGAAAACCGGTAAACCTATCACTGGTTTATACGCTGCAGGCGAAGTG ACTGGTGGTGTTCACGGTGCTAACCGTTTAGGTGGTAACGCTATCTCTGATATCGTCACC TACGGCCGTATCGCGGGTGCATCTGCCGCTAAATTCGCTAAAGATAATTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P83223 UniProtKB Entry Name FRDA_SHEON GenBank Protein ID 24346572 GenBank Gene ID AE014299 PDB ID(s) 1D4C, 1D4D, 1D4E KEGG ID son:SO_0970 NCBI Gene ID 1168814 - General References
- Tsapin AI, Vandenberghe I, Nealson KH, Scott JH, Meyer TE, Cusanovich MA, Harada E, Kaizu T, Akutsu H, Leys D, Van Beeumen JJ: Identification of a small tetraheme cytochrome c and a flavocytochrome c as two of the principal soluble cytochromes c in Shewanella oneidensis strain MR1. Appl Environ Microbiol. 2001 Jul;67(7):3236-44. [Article]
- Heidelberg JF, Paulsen IT, Nelson KE, Gaidos EJ, Nelson WC, Read TD, Eisen JA, Seshadri R, Ward N, Methe B, Clayton RA, Meyer T, Tsapin A, Scott J, Beanan M, Brinkac L, Daugherty S, DeBoy RT, Dodson RJ, Durkin AS, Haft DH, Kolonay JF, Madupu R, Peterson JD, Umayam LA, White O, Wolf AM, Vamathevan J, Weidman J, Impraim M, Lee K, Berry K, Lee C, Mueller J, Khouri H, Gill J, Utterback TR, McDonald LA, Feldblyum TV, Smith HO, Venter JC, Nealson KH, Fraser CM: Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis. Nat Biotechnol. 2002 Nov;20(11):1118-23. Epub 2002 Oct 7. [Article]
- Leys D, Tsapin AS, Nealson KH, Meyer TE, Cusanovich MA, Van Beeumen JJ: Structure and mechanism of the flavocytochrome c fumarate reductase of Shewanella putrefaciens MR-1. Nat Struct Biol. 1999 Dec;6(12):1113-7. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Fumaric acid investigational unknown target Details Flavin adenine dinucleotide approved unknown target Details Albendazole approved, vet_approved unknown target inhibitor Details