Albendazole
Identification
- Name
- Albendazole
- Accession Number
- DB00518
- Description
A benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)
- Type
- Small Molecule
- Groups
- Approved, Vet approved
- Structure
Structure for Albendazole (DB00518)
- Weight
- Average: 265.331
Monoisotopic: 265.088497429 - Chemical Formula
- C12H15N3O2S
- Synonyms
- (5-(propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester
- 5-(propylthio)-2-carbomethoxyaminobenzimidazole
- Albendazol
- Albendazole
- Albendazolum
- Eskazole
- O-methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate
- Proftril
- External IDs
- NSC-220008
- RS-8852
- SK&F-62979
- SKF 62979
Pharmacology
- Indication
For the treatment of parenchymal neurocysticercosis due to active lesions caused by larval forms of the pork tapeworm, Taenia solium and for the treatment of cystic hydatid disease of the liver, lung, and peritoneum, caused by the larval form of the dog tapeworm, Echinococcus granulosus.
- Associated Conditions
- Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More- Pharmacodynamics
Albendazole is a broad-spectrum anthelmintic. The principal mode of action for albendazole is by its inhibitory effect on tubulin polymerization which results in the loss of cytoplasmic microtubules.
- Mechanism of action
Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by diminishing its energy production, ultimately leading to immobilization and death of the parasite. It works by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. As cytoplasmic microtubules are critical in promoting glucose uptake in larval and adult stages of the susceptible parasites, the glycogen stores of the parasites are depleted. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth.
Target Actions Organism NTubulin alpha-1A chain inhibitorHumans ATubulin beta-2 chain inhibitorPig roundworm NTubulin beta-4B chain inhibitorHumans UFumarate reductase flavoprotein subunit inhibitorShewanella oneidensis (strain MR-1) - Absorption
Poorly absorbed from the gastrointestinal tract due to its low aqueous solubility. Oral bioavailability appears to be enhanced when coadministered with a fatty meal (estimated fat content 40 g)
- Volume of distribution
- Not Available
- Protein binding
70% bound to plasma protein
- Metabolism
Hepatic. Rapidly converted in the liver to the primary metabolite, albendazole sulfoxide, which is further metabolized to albendazole sulfone and other primary oxidative metabolites that have been identified in human urine.
Hover over products below to view reaction partners
- Route of elimination
Albendazole is rapidly converted in the liver to the primary metabolite, albendazole sulfoxide, which is further metabolized to albendazole sulfone and other primary oxidative metabolites that have been identified in human urine. Urinary excretion of albendazole sulfoxide is a minor elimination pathway with less than 1% of the dose recovered in the urine. Biliary elimination presumably accounts for a portion of the elimination as evidenced by biliary concentrations of albendazole sulfoxide similar to those achieved in plasma.
- Half-life
Terminal elimination half-life ranges from 8 to 12 hours (single dose, 400mg).
- Clearance
- Not Available
- Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More- Toxicity
Symptoms of overdose include elevated liver enzymes, headaches, hair loss, low levels of white blood cells (neutropenia), fever, and itching.
- Affected organisms
- Helminthic Microorganisms
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Unlock Additional DataAbametapir The serum concentration of Albendazole can be increased when it is combined with Abametapir. Abatacept The metabolism of Albendazole can be increased when combined with Abatacept. Abiraterone The serum concentration of Albendazole can be increased when it is combined with Abiraterone. Acalabrutinib The metabolism of Albendazole can be decreased when combined with Acalabrutinib. Acenocoumarol The metabolism of Acenocoumarol can be decreased when combined with Albendazole. Acetaminophen The metabolism of Albendazole can be increased when combined with Acetaminophen. Acetazolamide The metabolism of Albendazole can be decreased when combined with Acetazolamide. Acyclovir The metabolism of Acyclovir can be decreased when combined with Albendazole. Adalimumab The metabolism of Albendazole can be increased when combined with Adalimumab. Agomelatine The metabolism of Agomelatine can be decreased when combined with Albendazole. Additional Data Available- Extended DescriptionExtended Description
Extended description of the mechanism of action and particular properties of each drug interaction.
Learn more - Severity
- Evidence Level
- ActionAction
An effect category for each drug interaction. Know how this interaction affects the subject drug.
Learn more
- Food Interactions
- Take with a high fat meal. A high fat meal increases solubility and absorption. Take with food when treating systemic infections.
Products
- International/Other Brands
- Abentel (Aristopharma) / ABZ (Indoco) / Acure (Pharmix) / Adazol (Roemmers) / AL (Radicura) / Band (Vensat) / Bandy (Mankind) / Bazole (Neutro Pharma) / Ben-A (Acme) / Benrod (Invision) / Bentil (Alliance) / Benzol (Mercury Lab) / Benzole (Flamingo Pharmacueticals) / Bevindazol (Vincenti) / Biwom (Zydus) / Bruzol (Bruluart) / Buxol (Buffington's) / Cental (Brisafarma) / Champs (CCM) / Ciclopar (Weider) / Cidazole (Juggat) / Clearworm (Invision) / Dalben (Krka) / Despar (Icofarma) / Eskazole (GlaxoSmithKline) / Valbazen / Zolben (Sanofi-Aventis)
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Unlock Additional DataAlbendazole Tablet, film coated 200 mg/1 Oral Lineage Therapeutics Inc 2018-09-24 2021-07-31 US 
Albendazole Tablet, film coated 200 mg/1 Oral Amneal Pharmaceuticals of New York Llc 1996-06-11 Not applicable US Albenza Tablet, film coated 200 mg/1 Oral Department Of State Health Services, Pharmacy Branch 1996-06-11 2019-09-30 US Albenza Tablet, film coated 200 mg/1 Oral Amedra Pharmaceuticals LLC 1996-06-11 2020-08-31 US Albenza Tablet, film coated 200 mg/1 Oral McKesson Corporation dba RX Pak 1996-06-11 2019-09-01 US Albenza Tablet, film coated 200 mg/1 Oral Preferreed Pharmaceuticals Inc. 2011-03-29 2013-06-10 US Albenza Tablet, film coated 200 mg/1 Oral Amneal Pharmaceuticals LLC 1996-06-11 Not applicable US Albenza Tablet, film coated 200 mg/1 Oral Central Texas Community Health Centers 1996-06-11 Not applicable US Albenza Tablet, chewable 200 mg/1 Oral Amedra Pharmaceuticals LLC 2015-09-03 2015-09-03 US Albenza Tablet, film coated 200 mg/1 Oral Glaxosmithkline Inc 1996-09-26 2012-09-30 US Additional Data Available- Application NumberApplication Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
Learn more - Product CodeProduct Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
Learn more
- Generic Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Unlock Additional DataAlbendazole Tablet, film coated 200 mg/1 Oral Cadila Healthcare Limited 2018-12-17 Not applicable US Albendazole Tablet 200 mg/1 Oral Cipla USA Inc. 2018-09-24 Not applicable US Albendazole Tablet, film coated 200 mg/1 Oral Actavis Pharma, Inc. 2019-06-13 Not applicable US Albendazole Tablet 200 mg/1 Oral Golden State Medical Supply 2019-05-14 Not applicable US Albendazole Tablet, film coated 200 mg/1 Oral Northstar Rx Llc. 2019-04-19 Not applicable US Albendazole Tablet 200 mg/1 Oral Mark Cuban Cost Plus Drug Company, PBC 2020-08-19 Not applicable US Albendazole Tablet 200 mg/1 Oral Edenbridge Pharmaceuticals LLC. 2019-05-17 Not applicable US Albendazole Tablet, film coated 200 mg/1 Oral Zydus Pharmaceuticals (USA) Inc. 2018-12-17 Not applicable US Albendazole 200 mg Tablet, film coated 200 mg/1 Oral Vivimed Labs Limited 2018-12-15 2019-11-26 US Albendazole 200 mg Tablet, film coated 200 mg/1 Oral Camber Pharmaceuticals 2018-12-15 Not applicable US Additional Data Available- Application NumberApplication Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
Learn more - Product CodeProduct Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
Learn more
- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Unlock Additional DataZentel Tablet 400 mg/1 Oral OASIS TRADING 2018-11-15 Not applicable US Additional Data Available- Application NumberApplication Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
Learn more - Product CodeProduct Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
Learn more
- Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Zentel Albendazole (400 mg/1) Tablet Oral OASIS TRADING 2018-11-15 Not applicable US
Categories
- ATC Codes
- P02CA03 — Albendazole
- Drug Categories
- Acids, Acyclic
- Anthelmintics
- Anti-Infective Agents
- Anticestodal Agents
- Antihelminthic
- Antimitotic Agents
- Antinematodal Agents
- Antiparasitic Agents
- Antiparasitic Products, Insecticides and Repellents
- Antiplatyhelmintic Agents
- Benzimidazole Derivatives
- Benzimidazoles
- Carbamates
- Cytochrome P-450 CYP1A2 Inducers
- Cytochrome P-450 CYP1A2 Inducers (strong)
- Cytochrome P-450 CYP1A2 Substrates
- Cytochrome P-450 CYP2C19 Substrates
- Cytochrome P-450 CYP3A Substrates
- Cytochrome P-450 CYP3A4 Substrates
- Cytochrome P-450 CYP3A4 Substrates (strength unknown)
- Cytochrome P-450 Enzyme Inducers
- Cytochrome P-450 Substrates
- Heterocyclic Compounds, Fused-Ring
- Mitosis Modulators
- P-glycoprotein substrates
- Tubulin Modulators
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as 2-benzimidazolylcarbamic acid esters. These are aromatic heteropolycyclic compounds that contain a carbamic acid ester group, which is N-linked to the C2-atom of a benzimidazole moiety.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Benzimidazoles
- Sub Class
- 2-benzimidazolylcarbamic acid esters
- Direct Parent
- 2-benzimidazolylcarbamic acid esters
- Alternative Parents
- Thiophenol ethers / Alkylarylthioethers / Imidazoles / Heteroaromatic compounds / Carbamate esters / Organic carbonic acids and derivatives / Sulfenyl compounds / Azacyclic compounds / Organopnictogen compounds / Organonitrogen compounds show 3 more
- Substituents
- 2-benzimidazolylcarbamic acid ester / Alkylarylthioether / Aromatic heteropolycyclic compound / Aryl thioether / Azacycle / Azole / Benzenoid / Carbamic acid ester / Carbonic acid derivative / Carbonyl group show 13 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- carbamate ester, benzimidazoles, benzimidazolylcarbamate fungicide (CHEBI:16664) / a small molecule (ALBENDAZOLE)
Chemical Identifiers
- UNII
- F4216019LN
- CAS number
- 54965-21-8
- InChI Key
- HXHWSAZORRCQMX-UHFFFAOYSA-N
- InChI
- InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
- IUPAC Name
- methyl N-[6-(propylsulfanyl)-1H-1,3-benzodiazol-2-yl]carbamate
- SMILES
- CCCSC1=CC2=C(C=C1)N=C(NC(=O)OC)N2
References
- Synthesis Reference
Gyurik, R.J. and Theodorides, VJ.; US. Patent 3,915,986; October 28,1975; assigned to Smith Kline Corp.
US3915986- General References
- Molina AJ, Merino G, Prieto JG, Real R, Mendoza G, Alvarez AI: Absorption and metabolism of albendazole after intestinal ischemia/reperfusion. Eur J Pharm Sci. 2007 May;31(1):16-24. Epub 2007 Feb 6. [PubMed:17350811]
- Oxberry ME, Reynoldson JA, Thompson RC: The binding and distribution of albendazole and its principal metabolites in Giardia duodenalis. J Vet Pharmacol Ther. 2000 Jun;23(3):113-20. [PubMed:11110097]
- Ramirez T, Benitez-Bribiesca L, Ostrosky-Wegman P, Herrera LA: In vitro effects of albendazole and its metabolites on the cell proliferation kinetics and micronuclei frequency of stimulated human lymphocytes. Arch Med Res. 2001 Mar-Apr;32(2):119-22. [PubMed:11343808]
- Haque A, Hollister WS, Willcox A, Canning EU: The antimicrosporidial activity of albendazole. J Invertebr Pathol. 1993 Sep;62(2):171-7. [PubMed:8228321]
- FDA Approved Drugs Products: Albendazole Oral Tablets [Link]
- External Links
- Human Metabolome Database
- HMDB0014659
- KEGG Drug
- D00134
- KEGG Compound
- C01779
- PubChem Compound
- 2082
- PubChem Substance
- 46506472
- ChemSpider
- 1998
- BindingDB
- 50241293
- 430
- ChEBI
- 16664
- ChEMBL
- CHEMBL1483
- ZINC
- ZINC000017146904
- Therapeutic Targets Database
- DAP000951
- PharmGKB
- PA164746058
- PDBe Ligand
- ALW
- RxList
- RxList Drug Page
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Albendazole
- MSDS
- Download (74.4 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Prevention Intestinal Diseases, Parasitic 1 4 Completed Prevention Village Children 1 4 Completed Treatment Anemia / Worm Infections 1 4 Completed Treatment Ascariasis / Trichuriasis 1 4 Completed Treatment Disease Transmission, Infectious / Helminthiasis / Nematode Infection 1 4 Completed Treatment Filarial; Infestation 1 4 Completed Treatment Helminth Infection / Lymphatic Filariasis 1 4 Completed Treatment Helminthiasis / Intestinal Diseases 1 4 Completed Treatment Hookworm Infection 1 4 Completed Treatment Infection by Trichuris Trichiura 1
Pharmacoeconomics
- Manufacturers
- Glaxosmithkline llc
- Packagers
- GlaxoSmithKline Inc.
- Medisca Inc.
- Southwood Pharmaceuticals
- Dosage Forms
Form Route Strength Suspension Oral 200 mg/5mL Capsule 200 mg Tablet 200 mg Tablet, coated Oral 400 mg Suspension Oral 2000 mg Tablet, coated Oral 200 mg Suspension Oral 2 g Tablet Oral 200 mg Tablet Oral 200 mg/1 Tablet, chewable Oral 200 mg/1 Tablet, film coated Oral 200 mg/1 Tablet Tablet, film coated 200 mg Suspension 200 mg/10ml Tablet, film coated 400 mg Suspension Oral 4 mg Tablet, chewable Oral Tablet 400 mg Tablet, coated 200 mg Suspension Suspension Oral 100 mg/5mL Suspension Oral Suspension Oral 4 g Syrup 200 mg/5mL Suspension Oral 400 mg/10mL Suspension Oral 4 % Tablet Oral 400 mg/1 Tablet Oral 400 MG Tablet, coated 400 MG Tablet, film coated Oral 200 mg - Prices
Unit description Cost Unit Albenza 200 mg tablet 1.91USD tablet Albendazole powder 0.41USD g DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 208-210 Gyurik, R.J. and Theodorides, VJ.; US. Patent 3,915,986; October 28,1975; assigned to Smith Kline Corp. water solubility Practically insoluble Not Available logP 2.7 Not Available - Predicted Properties
Property Value Source Water Solubility 0.0228 mg/mL ALOGPS logP 3.22 ALOGPS logP 3.2 ChemAxon logS -4.1 ALOGPS pKa (Strongest Acidic) 9.51 ChemAxon pKa (Strongest Basic) 4.27 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 3 ChemAxon Hydrogen Donor Count 2 ChemAxon Polar Surface Area 67.01 Å2 ChemAxon Rotatable Bond Count 5 ChemAxon Refractivity 73.01 m3·mol-1 ChemAxon Polarizability 29.3 Å3 ChemAxon Number of Rings 2 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9944 Blood Brain Barrier + 0.9381 Caco-2 permeable - 0.8957 P-glycoprotein substrate Non-substrate 0.6637 P-glycoprotein inhibitor I Non-inhibitor 0.6928 P-glycoprotein inhibitor II Non-inhibitor 0.6089 Renal organic cation transporter Non-inhibitor 0.8433 CYP450 2C9 substrate Non-substrate 0.7742 CYP450 2D6 substrate Substrate 0.8918 CYP450 3A4 substrate Non-substrate 0.6147 CYP450 1A2 substrate Inhibitor 0.9106 CYP450 2C9 inhibitor Non-inhibitor 0.907 CYP450 2D6 inhibitor Non-inhibitor 0.9231 CYP450 2C19 inhibitor Non-inhibitor 0.9025 CYP450 3A4 inhibitor Non-inhibitor 0.8347 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.8037 Ames test Non AMES toxic 0.7894 Carcinogenicity Non-carcinogens 0.9334 Biodegradation Not ready biodegradable 1.0 Rat acute toxicity 2.0752 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9707 hERG inhibition (predictor II) Non-inhibitor 0.8549
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Targets
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Inhibitor
- General Function
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
- Specific Function
- Gtp binding
- Gene Name
- TUBA1A
- Uniprot ID
- Q71U36
- Uniprot Name
- Tubulin alpha-1A chain
- Molecular Weight
- 50135.25 Da
References
- Ramirez T, Benitez-Bribiesca L, Ostrosky-Wegman P, Herrera LA: In vitro effects of albendazole and its metabolites on the cell proliferation kinetics and micronuclei frequency of stimulated human lymphocytes. Arch Med Res. 2001 Mar-Apr;32(2):119-22. [PubMed:11343808]
- Chu SW, Badar S, Morris DL, Pourgholami MH: Potent inhibition of tubulin polymerisation and proliferation of paclitaxel-resistant 1A9PTX22 human ovarian cancer cells by albendazole. Anticancer Res. 2009 Oct;29(10):3791-6. [PubMed:19846910]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Pig roundworm
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Structural constituent of cytoskeleton
- Specific Function
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
- Gene Name
- Not Available
- Uniprot ID
- F1L7U3
- Uniprot Name
- Tubulin beta-2 chain
- Molecular Weight
- 51336.46 Da
References
- Solana HD, Sallovitz JM, Lanusse CE, Rodriguez JA: Enantioselective binding of albendazole sulphoxide to cytosolic proteins from helminth parasites. Methods Find Exp Clin Pharmacol. 2002 Jan-Feb;24(1):7-13. [PubMed:11980387]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Inhibitor
- General Function
- Unfolded protein binding
- Specific Function
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
- Gene Name
- TUBB4B
- Uniprot ID
- P68371
- Uniprot Name
- Tubulin beta-4B chain
- Molecular Weight
- 49830.72 Da
References
- Solana HD, Sallovitz JM, Lanusse CE, Rodriguez JA: Enantioselective binding of albendazole sulphoxide to cytosolic proteins from helminth parasites. Methods Find Exp Clin Pharmacol. 2002 Jan-Feb;24(1):7-13. [PubMed:11980387]
- Chu SW, Badar S, Morris DL, Pourgholami MH: Potent inhibition of tubulin polymerisation and proliferation of paclitaxel-resistant 1A9PTX22 human ovarian cancer cells by albendazole. Anticancer Res. 2009 Oct;29(10):3791-6. [PubMed:19846910]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Shewanella oneidensis (strain MR-1)
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Succinate dehydrogenase activity
- Specific Function
- Catalyzes fumarate reduction using artificial electron donors such as methyl viologen. The physiological reductant is unknown, but evidence indicates that flavocytochrome c participates in electron...
- Gene Name
- Not Available
- Uniprot ID
- P83223
- Uniprot Name
- Fumarate reductase flavoprotein subunit
- Molecular Weight
- 62447.475 Da
References
- Barrowman MM, Marriner SE, Bogan JA: The fumarate reductase system as a site of anthelmintic attack in Ascaris suum. Biosci Rep. 1984 Oct;4(10):879-83. [PubMed:6518278]
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inducer
- General Function
- Vitamin d 24-hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
- Gene Name
- CYP1A1
- Uniprot ID
- P04798
- Uniprot Name
- Cytochrome P450 1A1
- Molecular Weight
- 58164.815 Da
References
- Bapiro TE, Andersson TB, Otter C, Hasler JA, Masimirembwa CM: Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42. Epub 2002 Oct 2. [PubMed:12451431]
- Asteinza J, Camacho-Carranza R, Reyes-Reyes RE, Dorado-Gonzalez V V, Espinosa-Aguirre JJ: Induction of cytochrome P450 enzymes by albendazole treatment in the rat. Environ Toxicol Pharmacol. 2000 Dec;9(1-2):31-37. [PubMed:11137466]
- FDA Approved Drugs Products: Albendazole Oral Tablets [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inducer
- Curator comments
- Data supporting these enzyme actions are limited to in vitro studies.
- General Function
- Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
- Gene Name
- CYP1A2
- Uniprot ID
- P05177
- Uniprot Name
- Cytochrome P450 1A2
- Molecular Weight
- 58293.76 Da
References
- Asteinza J, Camacho-Carranza R, Reyes-Reyes RE, Dorado-Gonzalez V V, Espinosa-Aguirre JJ: Induction of cytochrome P450 enzymes by albendazole treatment in the rat. Environ Toxicol Pharmacol. 2000 Dec;9(1-2):31-37. [PubMed:11137466]
- Bapiro TE, Andersson TB, Otter C, Hasler JA, Masimirembwa CM: Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42. Epub 2002 Oct 2. [PubMed:12451431]
- FDA Approved Drugs Products: Albendazole Oral Tablets [Link]
- Albendazole FDA label [File]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Vitamin d3 25-hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
- Gene Name
- CYP3A4
- Uniprot ID
- P08684
- Uniprot Name
- Cytochrome P450 3A4
- Molecular Weight
- 57342.67 Da
References
- Li XQ, Bjorkman A, Andersson TB, Gustafsson LL, Masimirembwa CM: Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42. Epub 2003 Aug 12. [PubMed:12920490]
- Rawden HC, Kokwaro GO, Ward SA, Edwards G: Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes. Br J Clin Pharmacol. 2000 Apr;49(4):313-22. doi: 10.1046/j.1365-2125.2000.00170.x. [PubMed:10759686]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- Steroid hydroxylase activity
- Specific Function
- Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
- Gene Name
- CYP2C19
- Uniprot ID
- P33261
- Uniprot Name
- Cytochrome P450 2C19
- Molecular Weight
- 55930.545 Da
References
- Lee E, Wu Z, Shon JC, Liu KH: Danazol Inhibits Cytochrome P450 2J2 Activity in a Substrate-independent Manner. Drug Metab Dispos. 2015 Aug;43(8):1250-3. doi: 10.1124/dmd.115.064345. Epub 2015 Jun 5. [PubMed:26048912]
- Wu Z, Lee D, Joo J, Shin JH, Kang W, Oh S, Lee do Y, Lee SJ, Yea SS, Lee HS, Lee T, Liu KH: CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems. Antimicrob Agents Chemother. 2013 Nov;57(11):5448-56. doi: 10.1128/AAC.00843-13. Epub 2013 Aug 19. [PubMed:23959307]
Transporters
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- Xenobiotic-transporting atpase activity
- Specific Function
- Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
- Gene Name
- ABCB1
- Uniprot ID
- P08183
- Uniprot Name
- Multidrug resistance protein 1
- Molecular Weight
- 141477.255 Da
References
- Merino G, Alvarez AI, Prieto JG, Kim RB: The anthelminthic agent albendazole does not interact with p-glycoprotein. Drug Metab Dispos. 2002 Apr;30(4):365-9. [PubMed:11901088]
Drug created on June 13, 2005 07:24 / Updated on October 02, 2020 03:02
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