Hypoxanthine-guanine-xanthine phosphoribosyltransferase

BE0001516ProteinPlasmodium falciparum (isolate FCR-3 / Gambia)LACZ

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to the N(9) of hypoxanthine, guanine or xanthine, leading to IMP, GMP and XMP, respectively. It is acted on by 13 drugs in DrugBank.

Gene name
LACZ
UniProtKB entry
P20035Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
231 residues · 26,348 Da
Also known as
2.4.2.22 · HGPRT

Resolves to

Protein
UniProtP20035UniProt nameHGXR_PLAFG
Gene
GenBank9914
Structure
PDB1CJBPDB2VFAPDB3OZF
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Hypoxanthine-guanine-xanthine phosphoribosyltransferase, how selective are they, and which programs against it are still in active trials?

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