UDP-glucose 4-epimerase

BE0001521ProteinHumansGALE

Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. It is acted on by 8 drugs in DrugBank.

Gene name
GALE
UniProtKB entry
Q14376Swiss-Prot
Residues / weight
348 residues · 38,281 Da
Also known as
5.1.3.2 · Galactowaldenase · UDP-galactose 4-epimerase · UDP-GalNAc 4-epimerase · UDP-GlcNAc 4-epimerase

Resolves to

Protein
UniProtQ14376UniProt nameGALE_HUMAN
Gene
HGNCHGNC:4116NCBI Gene2582GenBank1119217GeneCardsGALE
Pharmacology
KEGGhsa:2582
Structure
PDB1EK5PDB1EK6PDB1HZJ
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on UDP-glucose 4-epimerase, how selective are they, and which programs against it are still in active trials?

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