N-acetylornithine carbamoyltransferase

BE0001526ProteinXanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)argF'

Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-acetyl-L-ornithine to produce N(2)-acetyl-L-citrulline. It is acted on by 2 drugs in DrugBank.

Gene name
argF'
UniProtKB entry
Q8P8J2Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
339 residues · 37,873 Da
Also known as
2.1.3.9 · Acetylornithine transcarbamylase · AOTCase · N-acetyl-L-ornithine transcarbamylase

Resolves to

Protein
UniProtQ8P8J2UniProt nameAOTC_XANCP
Gene
NCBI Gene998828GenBank21113385
Pharmacology
KEGGxcc:XCC2249
Structure
PDB3KZCPDB3KZKPDB3KZM
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on N-acetylornithine carbamoyltransferase, and which indications are they being tested in?

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