Complement C1s subcomponent

BE0001529ProteinHumansC1S

Component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the... It is acted on by 13 drugs in DrugBank.

Gene name
C1S
UniProtKB entry
P09871Swiss-Prot
Cellular location
Secreted
Residues / weight
688 residues · 76,684 Da
Also known as
3.4.21.42 · C1 esterase · Complement component 1 subcomponent s

Resolves to

Protein
UniProtP09871UniProt nameC1S_HUMAN
Gene
HGNCHGNC:1247NCBI Gene716GenBank763110GeneCardsC1S
Pharmacology
IUPHAR/GtoPdb2335KEGGhsa:716
Structure
PDB1ELVPDB1NZIPDB4J1Y
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Complement C1s subcomponent, how selective are they, and which programs against it are still in active trials?

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