Phospholipase C

Details

Name
Phospholipase C
Kind
protein
Synonyms
  • 3.1.4.3
  • Cereolysin A
  • Phosphatidylcholine cholinephosphohydrolase
  • PLC
Gene Name
plc
UniProtKB Entry
P09598Swiss-Prot
Organism
Bacillus cereus
NCBI Taxonomy ID
1396
Amino acid sequence
>lcl|BSEQ0011104|Phospholipase C
MKKKVLALAAAITVVAPLQSVAFAHENDGGSKIKIVHRWSAEDKHKEGVNSHLWIVNRAI
DIMSRNTTLVKQDRVAQLNEWRTELENGIYAADYENPYYDNSTFASHFYDPDNGKTYIPF
AKQAKETGAKYFKLAGESYKNKDMKQAFFYLGLSLHYLGDVNQPMHAANFTNLSYPQGFH
SKYENFVDTIKDNYKVTDGNGYWNWKGTNPEEWIHGAAVVAKQDYSGIVNDNTKDWFVKA
AVSQEYADKWRAEVTPMTGKRLMDAQRVTAGYIQLWFDTYGDR
Number of residues
283
Molecular Weight
32383.1
Theoretical pI
7.93
GO Classification
Functions
phosphatidylcholine phospholipase C activity / zinc ion binding
Processes
hemolysis in other organism
General Function
Required, with sphingomyelinase, to effect target cell lysis (hemolysis).
Specific Function
phosphatidylcholine phospholipase C activity
Pfam Domain Function
Signal Regions
1-24
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0003096|852 bp
ATGAAAAAGAAAGTACTTGCTTTAGCAGCAGCTATTACAGTAGTAGCTCCTTTACAAAGC
GTTGCATTTGCTCATGAAAATGATGGGGGAAGTAAAATAAAAATAGTTCACCGCTGGTCT
GCTGAAGATAAACATAAAGAAGGTGTAAATTCTCATTTATGGATTGTAAACCGTGCGATT
GATATTATGTCTCGCAATACAACACTTGTAAAACAAGATCGAGTTGCACAATTAAATGAA
TGGCGTACGGAGTTAGAGAACGGTATTTATGCTGCTGACTATGAAAATCCTTATTATGAT
AATAGCACATTTGCTTCACATTTCTATGATCCAGACAATGGAAAAACATATATTCCATTT
GCAAAGCAGGCAAAAGAAACTGGCGCTAAATATTTTAAATTAGCTGGTGAATCATACAAA
AATAAAGATATGAAACAAGCATTCTTCTATTTAGGATTATCTCTTCATTATTTAGGAGAT
GTAAACCAACCGATGCATGCGGCAAACTTTACAAATCTTTCATATCCACAAGGATTCCAT
TCTAAATATGAAAACTTTGTAGATACGATAAAAGATAATTATAAAGTAACGGATGGAAAT
GGATATTGGAACTGGAAAGGTACAAATCCAGAAGAGTGGATTCATGGAGCGGCAGTAGTA
GCGAAACAAGATTACTCTGGAATTGTAAATGATAATACGAAAGATTGGTTCGTAAAAGCA
GCTGTGTCACAAGAATATGCAGATAAATGGCGCGCTGAAGTTACACCAATGACAGGTAAG
CGATTAATGGATGCACAACGTGTTACTGCTGGATACATTCAGCTTTGGTTTGATACGTAC
GGAGATCGTTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP09598
UniProtKB Entry NamePHLC_BACCE
GenBank Protein ID312906
GenBank Gene IDX64141
PDB ID(s)1AH7, 1P5X, 1P6D, 1P6E, 2FFZ, 2FGN, 2HUC
General References
  1. Johansen T, Holm T, Guddal PH, Sletten K, Haugli FB, Little C: Cloning and sequencing of the gene encoding the phosphatidylcholine-preferring phospholipase C of Bacillus cereus. Gene. 1988 May 30;65(2):293-304. [Article]
  2. Gavrilenko IV, Baida GE, Karpov AV, Kuz'min NP: [Nucleotide sequence of phospholipase C and sphingomyelinase genes from Bacillus cereus BKM-B164]. Bioorg Khim. 1993 Jan;19(1):133-8. [Article]
  3. Yamada A, Tsukagoshi N, Udaka S, Sasaki T, Makino S, Nakamura S, Little C, Tomita M, Ikezawa H: Nucleotide sequence and expression in Escherichia coli of the gene coding for sphingomyelinase of Bacillus cereus. Eur J Biochem. 1988 Aug 1;175(2):213-20. [Article]
  4. Otnaess AB, Little C, Sletten K, Wallin R, Johnsen S, Flengsrud R, Prydz H: Some characteristics of phospholipase C from Bacillus cereus. Eur J Biochem. 1977 Oct 3;79(2):459-68. [Article]
  5. Ikeda K, Inoue S, Amasaki C, Teshima K, Ikezawa H: Kinetics of the hydrolysis of monodispersed and micellar phosphatidylcholines catalyzed by a phospholipase C from Bacillus cereus. J Biochem. 1991 Jul;110(1):88-95. [Article]
  6. Hough E, Hansen LK, Birknes B, Jynge K, Hansen S, Hordvik A, Little C, Dodson E, Derewenda Z: High-resolution (1.5 A) crystal structure of phospholipase C from Bacillus cereus. Nature. 1989 Mar 23;338(6213):357-60. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
1,2-Di-N-Pentanoyl-Sn-Glycero-3-DithiophosphocholineexperimentalunknowntargetDetails
(3s)-3,4-Di-N-Hexanoyloxybutyl-1-PhosphocholineexperimentalunknowntargetDetails