Phospholipase C
Details
- Name
- Phospholipase C
- Kind
- protein
- Synonyms
- 3.1.4.3
- Cereolysin A
- Phosphatidylcholine cholinephosphohydrolase
- PLC
- Gene Name
- plc
- UniProtKB Entry
- P09598Swiss-Prot
- Organism
- Bacillus cereus
- NCBI Taxonomy ID
- 1396
- Amino acid sequence
>lcl|BSEQ0011104|Phospholipase C MKKKVLALAAAITVVAPLQSVAFAHENDGGSKIKIVHRWSAEDKHKEGVNSHLWIVNRAI DIMSRNTTLVKQDRVAQLNEWRTELENGIYAADYENPYYDNSTFASHFYDPDNGKTYIPF AKQAKETGAKYFKLAGESYKNKDMKQAFFYLGLSLHYLGDVNQPMHAANFTNLSYPQGFH SKYENFVDTIKDNYKVTDGNGYWNWKGTNPEEWIHGAAVVAKQDYSGIVNDNTKDWFVKA AVSQEYADKWRAEVTPMTGKRLMDAQRVTAGYIQLWFDTYGDR
- Number of residues
- 283
- Molecular Weight
- 32383.1
- Theoretical pI
- 7.93
- GO Classification
- Functionsphosphatidylcholine phospholipase C activity / zinc ion bindingProcesseshemolysis in other organism
- General Function
- Required, with sphingomyelinase, to effect target cell lysis (hemolysis).
- Specific Function
- phosphatidylcholine phospholipase C activity
- Pfam Domain Function
- Zn_dep_PLPC (PF00882)
- Signal Regions
- 1-24
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0003096|852 bp ATGAAAAAGAAAGTACTTGCTTTAGCAGCAGCTATTACAGTAGTAGCTCCTTTACAAAGC GTTGCATTTGCTCATGAAAATGATGGGGGAAGTAAAATAAAAATAGTTCACCGCTGGTCT GCTGAAGATAAACATAAAGAAGGTGTAAATTCTCATTTATGGATTGTAAACCGTGCGATT GATATTATGTCTCGCAATACAACACTTGTAAAACAAGATCGAGTTGCACAATTAAATGAA TGGCGTACGGAGTTAGAGAACGGTATTTATGCTGCTGACTATGAAAATCCTTATTATGAT AATAGCACATTTGCTTCACATTTCTATGATCCAGACAATGGAAAAACATATATTCCATTT GCAAAGCAGGCAAAAGAAACTGGCGCTAAATATTTTAAATTAGCTGGTGAATCATACAAA AATAAAGATATGAAACAAGCATTCTTCTATTTAGGATTATCTCTTCATTATTTAGGAGAT GTAAACCAACCGATGCATGCGGCAAACTTTACAAATCTTTCATATCCACAAGGATTCCAT TCTAAATATGAAAACTTTGTAGATACGATAAAAGATAATTATAAAGTAACGGATGGAAAT GGATATTGGAACTGGAAAGGTACAAATCCAGAAGAGTGGATTCATGGAGCGGCAGTAGTA GCGAAACAAGATTACTCTGGAATTGTAAATGATAATACGAAAGATTGGTTCGTAAAAGCA GCTGTGTCACAAGAATATGCAGATAAATGGCGCGCTGAAGTTACACCAATGACAGGTAAG CGATTAATGGATGCACAACGTGTTACTGCTGGATACATTCAGCTTTGGTTTGATACGTAC GGAGATCGTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P09598 UniProtKB Entry Name PHLC_BACCE GenBank Protein ID 312906 GenBank Gene ID X64141 PDB ID(s) 1AH7, 1P5X, 1P6D, 1P6E, 2FFZ, 2FGN, 2HUC - General References
- Johansen T, Holm T, Guddal PH, Sletten K, Haugli FB, Little C: Cloning and sequencing of the gene encoding the phosphatidylcholine-preferring phospholipase C of Bacillus cereus. Gene. 1988 May 30;65(2):293-304. [Article]
- Gavrilenko IV, Baida GE, Karpov AV, Kuz'min NP: [Nucleotide sequence of phospholipase C and sphingomyelinase genes from Bacillus cereus BKM-B164]. Bioorg Khim. 1993 Jan;19(1):133-8. [Article]
- Yamada A, Tsukagoshi N, Udaka S, Sasaki T, Makino S, Nakamura S, Little C, Tomita M, Ikezawa H: Nucleotide sequence and expression in Escherichia coli of the gene coding for sphingomyelinase of Bacillus cereus. Eur J Biochem. 1988 Aug 1;175(2):213-20. [Article]
- Otnaess AB, Little C, Sletten K, Wallin R, Johnsen S, Flengsrud R, Prydz H: Some characteristics of phospholipase C from Bacillus cereus. Eur J Biochem. 1977 Oct 3;79(2):459-68. [Article]
- Ikeda K, Inoue S, Amasaki C, Teshima K, Ikezawa H: Kinetics of the hydrolysis of monodispersed and micellar phosphatidylcholines catalyzed by a phospholipase C from Bacillus cereus. J Biochem. 1991 Jul;110(1):88-95. [Article]
- Hough E, Hansen LK, Birknes B, Jynge K, Hansen S, Hordvik A, Little C, Dodson E, Derewenda Z: High-resolution (1.5 A) crystal structure of phospholipase C from Bacillus cereus. Nature. 1989 Mar 23;338(6213):357-60. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 1,2-Di-N-Pentanoyl-Sn-Glycero-3-Dithiophosphocholine experimental unknown target Details (3s)-3,4-Di-N-Hexanoyloxybutyl-1-Phosphocholine experimental unknown target Details