Nuclease P1

Details

Name
Nuclease P1
Kind
protein
Synonyms
  • 3.1.30.1
  • Deoxyribonuclease P1
  • Endonuclease P1
Gene Name
Not Available
UniProtKB Entry
P24289Swiss-Prot
Organism
Penicillium citrinum
NCBI Taxonomy ID
5077
Amino acid sequence
>lcl|BSEQ0016482|Nuclease P1
WGALGHATVAYVAQHYVSPEAASWAQGILGSSSSSYLASIASWADEYRLTSAGKWSASLH
FIDAEDNPPTNCNVDYERDCGSSGCSISAIANYTQRVSDSSLSSENHAEALRFLVHFIGD
MTQPLHDEAYAVGGNKINVTFDGYHDNLHSDWDTYMPQKLIGGHALSDAESWAKTLVQNI
ESGNYTAQAIGWIKGDNISEPITTATRWASDANALVCTVVMPHGAAALQTGDLYPTYYDS
VIDTIELQIAKGGYRLANWINEIHGSEIAK
Number of residues
270
Molecular Weight
29226.835
Theoretical pI
4.52
GO Classification
Functions
endonuclease activity / metal ion binding / nucleic acid binding
Processes
DNA catabolic process
Components
extracellular region
General Function
Hydrolyzes only single-stranded DNA and RNA without apparent specificity for bases.
Specific Function
endonuclease activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
Not Available
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP24289
UniProtKB Entry NameNUP1_PENCI
PDB ID(s)1AK0
General References
  1. Maekawa K, Tsunasawa S, Dibo G, Sakiyama F: Primary structure of nuclease P1 from Penicillium citrinum. Eur J Biochem. 1991 Sep 15;200(3):651-61. [Article]
  2. Volbeda A, Lahm A, Sakiyama F, Suck D: Crystal structure of Penicillium citrinum P1 nuclease at 2.8 A resolution. EMBO J. 1991 Jul;10(7):1607-18. [Article]
  3. Romier C, Dominguez R, Lahm A, Dahl O, Suck D: Recognition of single-stranded DNA by nuclease P1: high resolution crystal structures of complexes with substrate analogs. Proteins. 1998 Sep 1;32(4):414-24. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Thymidine-5'-(dithio)phosphateexperimentalunknowntargetDetails
Adenosine-5'-(Dithio)PhosphateexperimentalunknowntargetDetails