Oxysterols receptor LXR-beta

BE0001598ProteinHumansNR1H2

Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). It is acted on by 10 drugs in DrugBank.

Gene name
NR1H2
UniProtKB entry
P55055Swiss-Prot
Cellular location
Nucleus
Residues / weight
460 residues · 50,973 Da
Also known as
Liver X receptor beta · LXRB · NER · Nuclear receptor NER · Nuclear receptor subfamily 1 group H member 2

Resolves to

Protein
UniProtP55055UniProt nameNR1H2_HUMAN
Gene
HGNCHGNC:7965NCBI Gene7376GenBank641962GeneCardsNR1H2
Pharmacology
IUPHAR/GtoPdb601KEGGhsa:7376
Structure
PDB1P8DPDB1PQ6PDB1PQ9
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
23GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
39+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Oxysterols receptor LXR-beta, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In