NAD(P)H-dependent nitroreductase NfsB

BE0001616ProteinEscherichia coli (strain K12)nfsB

Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. It is acted on by 8 drugs in DrugBank.

Gene name
nfsB
UniProtKB entry
P38489Swiss-Prot
Residues / weight
217 residues · 23,905 Da
Also known as
1.-.-.- · 1.7.1.- · Dihydropteridine reductase · dprA · FMN-dependent nitroreductase

Resolves to

Protein
UniProtP38489UniProt nameNFSB_ECOLI
Gene
NCBI Gene945778GenBank538227
Pharmacology
KEGGecj:JW0567
Structure
PDB1DS7PDB1ICRPDB1ICU
Drugs

What you can answer from here — as of September 08, 2026

8DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NAD(P)H-dependent nitroreductase NfsB, how selective are they, and which programs against it are still in active trials?

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