Fluoromisonidazole F-18

DB14830InvestigationalSmall molecule

Fluoromisonidazole F-18 is under investigation in clinical trial NCT01507428 (Study of Positron Emission Tomography and Computed Tomography in Guiding Radiation Therapy in Patients With Stage III Non-small Cell Lung Cancer).

Mechanism: Pharmacologically active on NAD(P)H-dependent nitroreductase NfsB
Curator reviewed
Formula / weight: C₆H₈FN₃O₃ · 188.149 g/mol (avg)
Also known as: 18F-FMISO

Resolves to

Compound

UNII8MSY49469GCAS104613-87-8ChEMBLCHEMBL2037002

Structure

InChIKeyHIIJZYSUEJYLMX-JZRMKITLSA-NSMILESOC(C[18F])CN1C=CN=C1[N+]([O-])=O

Targets

P38489nfsB

What you can answer from here — as of July 10, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

13Clinical trialsPhase, status and sponsor resolved per trial

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with Fluoromisonidazole F-18, and which of those have an active Phase 3 trial?

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