This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Fluoromisonidazole F-18
- DrugBank Accession Number
- DB14830
- Background
Fluoromisonidazole F-18 is under investigation in clinical trial NCT01507428 (Study of Positron Emission Tomography and Computed Tomography in Guiding Radiation Therapy in Patients With Stage III Non-small Cell Lung Cancer).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Fluoromisonidazole F-18 (DB14830)
- Weight
- Average: 188.149
Monoisotopic: 188.057503797 - Chemical Formula
- C6H8FN3O3
- Synonyms
- 1-(2-Nitro-Imidazolyl)-3-[18F]Fluoro-2-Propanol
- 18F-MISO
- 18F-Misonidazole
- 1H-1-(3-[18F]Fluoro-2-Hydroxypropyl-2-Nitroimidazole 18F
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 8MSY49469G
- CAS number
- 104613-87-8
- InChI Key
- HIIJZYSUEJYLMX-JZRMKITLSA-N
- InChI
- InChI=1S/C6H8FN3O3/c7-3-5(11)4-9-2-1-8-6(9)10(12)13/h1-2,5,11H,3-4H2/i7-1
- IUPAC Name
- 1-(¹⁸F)fluoro-3-(2-nitro-1H-imidazol-1-yl)propan-2-ol
- SMILES
- OC(C[18F])CN1C=CN=C1[N+]([O-])=O
References
- General References
- Not Available
- External Links
- ChemSpider
- 396524
- ChEMBL
- CHEMBL2037002
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Active Not Recruiting Treatment Stage III Non-Small Cell Lung Cancer AJCC v7 / Stage IIIA Non-Small Cell Lung Cancer AJCC v7 / Stage IIIB Non-Small Cell Lung Cancer AJCC v7 1 2 Completed Diagnostic Adult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma 1 2 Completed Diagnostic Adult Liver Carcinoma / Cirrhosis of the Liver 1 2 Withdrawn Diagnostic Cancer of the Skin / Melanoma 1 0 Withdrawn Diagnostic Squamous Cell Carcinoma of the Head and Neck (SCCHN) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 5.39 mg/mL ALOGPS logP -0.46 ALOGPS logP 0.27 Chemaxon logS -1.6 ALOGPS pKa (Strongest Acidic) 13.64 Chemaxon pKa (Strongest Basic) 0.001 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 81.19 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 40.27 m3·mol-1 Chemaxon Polarizability 15.65 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at May 20, 2019 14:29 / Updated at December 01, 2022 11:28