(S)-2-haloacid dehalogenase

BE0001647ProteinPseudomonas sp. (strain YL)

Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids (PubMed:7490277, PubMed:9614112). It is acted on by 2 drugs in DrugBank.

UniProtKB entry
Q53464Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
232 residues · 26,176 Da
Also known as
2-haloalkanoic acid dehalogenase · 3.8.1.2 · Halocarboxylic acid halidohydrolase · L-2-haloacid dehalogenase · L-DEX

Resolves to

Protein
UniProtQ53464UniProt nameHAD_PSEUY
Gene
GenBank691747
Structure
PDB1JUDPDB1QH9PDB1ZRM
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on (S)-2-haloacid dehalogenase, and which indications are they being tested in?

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