Nucleoside deoxyribosyltransferase

Details

Name
Nucleoside deoxyribosyltransferase
Kind
protein
Synonyms
  • 2.4.2.6
  • N-deoxyribosyltransferase
Gene Name
ntd
UniProtKB Entry
Q9R5V5Swiss-Prot
Organism
Lactobacillus leichmannii
NCBI Taxonomy ID
28039
Amino acid sequence
>lcl|BSEQ0016521|Nucleoside deoxyribosyltransferase
MPKKTIYFGAGWFTDRQNKAYKEAMEALKENPTIDLENSYVPLDNQYKGIRVDEHPEYLH
DKVWATATYNNDLNGIKTNDIMLGVYIPDEEDVGLGMELGYALSQGKYVLLVIPDEDYGK
PINLMSWGVSDNVIKMSQLKDFNFNKPRFDFYEGAVY
Number of residues
157
Molecular Weight
18080.3
Theoretical pI
4.41
GO Classification
Functions
deoxyribonucleoside 5'-monophosphate N-glycosidase activity / nucleoside deoxyribosyltransferase activity
Processes
deoxyribonucleoside monophosphate catabolic process / nucleotide salvage
General Function
Catalyzes the cleavage of the glycosidic bond of 2'-deoxyribonucleosides and the transfer of the deoxyribosyl moiety to an acceptor purine or pyrimidine base.
Specific Function
nucleoside deoxyribosyltransferase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
Not Available
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9R5V5
UniProtKB Entry NameNTD_LACLE
PDB ID(s)1F8X, 1F8Y, 4HX9
General References
  1. Porter DJ, Merrill BM, Short SA: Identification of the active site nucleophile in nucleoside 2-deoxyribosyltransferase as glutamic acid 98. J Biol Chem. 1995 Jun 30;270(26):15551-6. [Article]
  2. Armstrong SR, Cook WJ, Short SA, Ealick SE: Crystal structures of nucleoside 2-deoxyribosyltransferase in native and ligand-bound forms reveal architecture of the active site. Structure. 1996 Jan 15;4(1):97-107. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
5-methyl-2'-deoxypseudouridineexperimentalunknowntargetDetails