Plasmepsin II

BE0001694ProteinPlasmodium falciparumPMII

During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation (PubMed:11782538, PubMed:15574427, PubMed:8844673). It is acted on by 8 drugs in DrugBank.

Gene name
PMII
UniProtKB entry
P46925Swiss-Prot
Cellular location
Vacuole
Residues / weight
453 residues · 51,489 Da
Also known as
3.4.23.39 · Aspartic hemoglobinase II · PFAPD · PfPM1 · Plasmepsin 2

Resolves to

Protein
UniProtP46925UniProt namePLM2_PLAFX
Gene
GenBank858754
Structure
PDB1J8JPDB1LEEPDB1LF2
Drugs

What you can answer from here — as of May 03, 2025

8DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Plasmepsin II, how selective are they, and which programs against it are still in active trials?

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