Histidinol dehydrogenase

BE0001751ProteinEscherichia coli (strain K12)hisD

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. It is acted on by 3 drugs in DrugBank.

Gene name
hisD
UniProtKB entry
P06988Swiss-Prot
Residues / weight
434 residues · 46,110 Da
Also known as
1.1.1.23 · HDH

Resolves to

Protein
UniProtP06988UniProt nameHISX_ECOLI
Gene
NCBI Gene946531GenBank41709
Pharmacology
KEGGecj:JW2002
Structure
PDB1K75PDB1KAEPDB1KAH
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Histidinol dehydrogenase, and which indications are they being tested in?

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