Elongation factor G

Details

Name
Elongation factor G
Kind
protein
Synonyms
  • EF-G
  • fus
Gene Name
fusA
UniProtKB Entry
P13551Swiss-Prot
Organism
Thermus thermophilus
NCBI Taxonomy ID
274
Amino acid sequence
>lcl|BSEQ0019178|Elongation factor G
MAVKVEYDLKRLRNIGIAAHIDAGKTTTTERILYYTGRIHKIGEVHEGAATMDFMEQERE
RGITITAAVTTCFWKDHRINIIDTPGHVDFTIEVERSMRVLDGAIVVFDSSQGVEPQSET
VWRQAEKYKVPRIAFANKMDKTGADLWLVIRTMQERLGARPVVMQLPIGREDTFSGIIDV
LRMKAYTYGNDLGTDIREIPIPEEYLDQAREYHEKLVEVAADFDENIMLKYLEGEEPTEE
ELVAAIRKGTIDLKITPVFLGSALKNKGVQLLLDAVVDYLPSPLDIPPIKGTTPEGEVVE
IHPDPNGPLAALAFKIMADPYVGRLTFIRVYSGTLTSGSYVYNTTKGRKERVARLLRMHA
NHREEVEELKAGDLGAVVGLKETITGDTLVGEDAPRVILESIEVPEPVIDVAIEPKTKAD
QEKLSQALARLAEEDPTFRVSTHPETGQTIISGMGELHLEIIVDRLKREFKVDANVGKPQ
VAYRETITKPVDVEGKFIRQTGGRGQYGHVKIKVEPLPRGSGFEFVNAIVGGVIPKEYIP
AVQKGIEEAMQSGPLIGFPVVDIKVTLYDGSYHEVDSSEMAFKIAGSMAIKEAVQKGDPV
ILEPIMRVEVTTPEEYMGDVIGDLNARRGQILGMEPRGNAQVIRAFVPLAEMFGYATDLR
SKTQGRGSFVMFFDHYQEVPKQVQEKLIKGQ
Number of residues
691
Molecular Weight
76878.69
Theoretical pI
5.09
GO Classification
Functions
GTP binding / GTPase activity / translation elongation factor activity
Components
cytoplasm
General Function
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Specific Function
GDP binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
Not Available
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP13551
UniProtKB Entry NameEFG_THETH
PDB ID(s)1FNM, 1IP8, 1IPM, 1IPO, 1IPR, 1JQM, 1JQS, 1KTV, 1PN6, 2BCW, 2BM0, 2BM1, 2BV3, 2J7K, 2OM7, 3IZP, 4M1K, 4MYT, 4MYU
General References
  1. al-Karadaghi S, Aevarsson A, Garber M, Zheltonosova J, Liljas A: The structure of elongation factor G in complex with GDP: conformational flexibility and nucleotide exchange. Structure. 1996 May 15;4(5):555-65. [Article]
  2. Laurberg M, Kristensen O, Martemyanov K, Gudkov AT, Nagaev I, Hughes D, Liljas A: Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site. J Mol Biol. 2000 Nov 3;303(4):593-603. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Guanosine-5'-DiphosphateexperimentalunknowntargetDetails
Fusidic acidapproved, investigationalyestargetinhibitorDetails