mRNA-capping enzyme
Details
- Name
- mRNA-capping enzyme
- Kind
- protein
- Synonyms
- GTP--RNA guanylyltransferase
- mRNA guanylyltransferase
- Gene Name
- Not Available
- UniProtKB Entry
- Q84424Swiss-Prot
- Organism
- PBCV-1
- NCBI Taxonomy ID
- 10506
- Amino acid sequence
>lcl|BSEQ0011303|mRNA-capping enzyme MVPPTINTGKNITTERAVLTLNGLQIKLHKVVGESRDDIVAKMKDLAMDDHKFPRLPGPN PVSIERKDFEKLKQNKYVVSEKTDGIRFMMFFTRVFGFKVCTIIDRAMTVYLLPFKNIPR VLFQGSIFDGELCVDIVEKKFAFVLFDAVVVSGVTVSQMDLASRFFAMKRSLKEFKNVPE DPAILRYKEWIPLEHPTIIKDHLKKANAIYHTDGLIIMSVDEPVIYGRNFNLFKLKPGTH HTIDFIIMSEDGTIGIFDPNLRKNVPVGKLDGYYNKGSIVECGFADGTWKYIQGRSDKNQ ANDRLTYEKTLLNIEENITIDELLDLFKWE
- Number of residues
- 330
- Molecular Weight
- 37831.715
- Theoretical pI
- 8.42
- GO Classification
- FunctionsGTP binding / mRNA guanylyltransferase activityProcesses7-methylguanosine mRNA capping
- General Function
- mRNA capping. Transfers a GMP cap onto the end of mRNA that terminates with a 5'-diphosphate tail.
- Specific Function
- ATP binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011304|mRNA-capping enzyme ATGGTTCCTCCCACAATCAACACCGGCAAAAATATCACTACCGAACGCGCCGTCTTGACG CTCAACGGTCTGCAAATAAAGCTGCATAAGGTTGTCGGAGAATCTCGCGATGATATCGTT GCCAAGATGAAAGATCTCGCTATGGACGACCATAAGTTCCCCAGGCTGCCGGGTCCCAAC CCGGTTAGCATTGAGCGAAAGGACTTTGAAAAATTGAAGCAGAATAAATACGTCGTATCG GAAAAGACGGATGGTATTCGGTTCATGATGTTTTTCACTCGGGTTTTCGGGTTCAAGGTG TGTACTATTATTGACCGCGCGATGACTGTATACCTTCTTCCTTTCAAGAACATTCCCCGA GTTCTATTTCAAGGTTCTATTTTCGATGGAGAGTTGTGCGTTGACATCGTCGAAAAGAAA TTTGCGTTTGTTCTATTTGACGCCGTCGTGGTGAGTGGTGTTACCGTGAGTCAGATGGAT CTTGCAAGTCGCTTCTTTGCGATGAAGAGGTCTCTTAAAGAGTTCAAGAATGTTCCCGAG GATCCCGCCATTCTTCGATACAAAGAATGGATTCCACTCGAGCATCCAACTATCATCAAG GACCATCTCAAAAAGGCCAATGCTATTTATCATACCGACGGTCTTATCATAATGAGCGTT GACGAACCTGTTATTTATGGACGGAATTTCAATTTGTTCAAGCTGAAGCCCGGGACCCAC CATACTATTGACTTCATTATCATGAGCGAAGATGGGACAATCGGCATCTTCGATCCTAAT TTGAGGAAGAATGTTCCCGTCGGAAAACTTGATGGTTATTACAATAAGGGTTCTATCGTA GAATGTGGATTCGCTGATGGAACGTGGAAATATATTCAGGGGCGTTCTGACAAAAACCAA GCAAATGATCGTTTGACATACGAAAAGACACTACTGAACATCGAGGAAAACATTACGATT GACGAATTGCTTGATTTGTTCAAATGGGAGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q84424 UniProtKB Entry Name MCE_PBCV1 GenBank Protein ID 1131446 GenBank Gene ID U42580 PDB ID(s) 1CKM, 1CKN, 1CKO KEGG ID vg:918242 NCBI Gene ID 918242 - General References
- Li Y, Lu Z, Burbank DE, Kutish GF, Rock DL, Van Etten JL: Analysis of 43 kb of the Chlorella virus PBCV-1 330-kb genome: map positions 45 to 88. Virology. 1995 Sep 10;212(1):134-50. [Article]
- Hakansson K, Doherty AJ, Shuman S, Wigley DB: X-ray crystallography reveals a large conformational change during guanyl transfer by mRNA capping enzymes. Cell. 1997 May 16;89(4):545-53. [Article]
- Hakansson K, Wigley DB: Structure of a complex between a cap analogue and mRNA guanylyl transferase demonstrates the structural chemistry of RNA capping. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1505-10. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Diguanosine-5'-Triphosphate experimental unknown target Details Guanosine-5'-Triphosphate experimental unknown target Details