Neocarzinostatin

Details

Name
Neocarzinostatin
Kind
protein
Synonyms
  • Mitomalcin
  • MMC
  • NCS
Gene Name
ncsA
UniProtKB Entry
P0A3S0Swiss-Prot
Organism
Streptomyces malayensis
NCBI Taxonomy ID
1918
Amino acid sequence
>lcl|BSEQ0011321|Neocarzinostatin
AAPTATVTPSSGLSDGTVVKVAGAGLQAGTAYDVGQCAWVDTGVLACNPADFSSVTADAN
GSASTSLTVRRSFEGFLFDGTRWGTVDCTTAACQVGLSDAAGNGPEGVAISFN
Number of residues
113
Molecular Weight
11096.03
Theoretical pI
3.83
GO Classification
Functions
DNA binding
Processes
defense response to bacterium
General Function
NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
Specific Function
DNA binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
Not Available
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP0A3S0
UniProtKB Entry NameNCZS_STRML
PDB ID(s)4JW3
General References
  1. Gao XL, Burkhart W: Two- and three-dimensional proton NMR studies of apo-neocarzinostatin. Biochemistry. 1991 Aug 6;30(31):7730-9. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Ncs-ChromophoreexperimentalunknowntargetDetails