Penicillin-binding protein 2X

BE0001868ProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)pbpX

A transpeptidase that forms peptide cross-links between adjacent glycan strands in cell wall peptidoglycan (PG). It is acted on by 4 drugs in DrugBank.

Gene name
pbpX
UniProtKB entry
P59676Swiss-Prot
Cellular location
Cell membrane
Residues / weight
750 residues · 82,343 Da
Also known as
PBP-2X

Resolves to

Protein
UniProtP59676UniProt namePBPX_STRR6
Gene
NCBI Gene934744GenBank47392
Pharmacology
KEGGspr:spr0304
Structure
PDB1PYY
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Penicillin-binding protein 2X, how selective are they, and which programs against it are still in active trials?

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