Cloxacillin is an antibiotic agent used for the treatment of beta-hemolytic streptococcal and pneumococcal infections as well as staphylococcal infections. A semi-synthetic penicillin antibiotic which is a chlorinated derivative of oxacillin.
- Mechanism
- Curator reviewed
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, cloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cloxacillin interferes with an autolysin inhibitor.
- Primary indication
- Cloxacillin is indicated for the treatment of beta-hemolytic streptococcal, pneumococcal, and staphylococcal infections (including beta-lactamase producing organisms).Curator reviewed · 4 structured indications
- Formula / weight
- C19H18ClN3O5S · 435.881 g/mol (avg)
- First approval
- Canada, 2013
Resolves to
LQOLIRLGBULYKD-JKIFEVAISA-NSMILES[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl)C(O)=OWhat you can answer from here — as of September 29, 2026
Which drugs share a target with Cloxacillin, and which of those have an active Phase 3 trial?
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