Heat shock protein HSP 90-beta

BE0001898ProteinHumansHSP90AB1

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. It is acted on by 26 drugs in DrugBank.

Gene name
HSP90AB1
UniProtKB entry
P08238Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
724 residues · 83,263 Da
Also known as
Heat shock 84 kDa · Heat shock protein family C member 3 · HSP 84 · HSP 90 · HSP84

Resolves to

Protein
UniProtP08238UniProt nameHS90B_HUMAN
Gene
HGNCHGNC:5258NCBI Gene3326GenBank306891GeneCardsHSP90AB1
Pharmacology
IUPHAR/GtoPdb2907KEGGhsa:3326
Structure
PDB1QZ2PDB1UYMPDB2L6J
Drugs

What you can answer from here — as of September 07, 2019

26DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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46GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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83+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Heat shock protein HSP 90-beta, and which indications are they being tested in?

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