XL-888

DB12981InvestigationalSmall molecule

XL888 has been used in trials studying the treatment of Cancer and Melanoma.

Mechanism: Pharmacologically active on Heat shock protein HSP 90-alpha and Heat shock protein HSP 90-beta
Curator reviewed
Formula / weight: C₂₉H₃₇N₅O₃ · 503.6358 g/mol (avg)
Code names: XL-888

Resolves to

Compound

Structure

InChIKeyLHGWWAFKVCIILM-HLRQEUIKSA-NSMILESCC[C@@H](C)NC1=C(C=C(C)C(=C1)C(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2C1=CC=C(C=N1)C(=O)C1CC1)C(N)=O

Targets

What you can answer from here — as of July 07, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

4Clinical trialsPhase, status and sponsor resolved per trial

10+ReferencesStructured and connected to the statements they support

Which drugs share a target with XL-888, and which of those have an active Phase 3 trial?

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