Octenidine
Star0
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Octenidine is an antiseptic agent used topically, on mucous membranes, and prior to surgery.
- Generic Name
- Octenidine
- DrugBank Accession Number
- DB12624
- Background
Octenidine is under investigation in clinical trial NCT02697162 (Antiseptic-coated Intermittent Urinary Catheter).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 550.92
Monoisotopic: 550.497448012 - Chemical Formula
- C36H62N4
- Synonyms
- Octenidine
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Treatment of Inflammation of mouth ••• ••• ••••••• - Associated Therapies
- Contraindications & Blackbox Warnings
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Octenidine dihydrochloride U84956NU4B 70775-75-6 SMGTYJPMKXNQFY-UHFFFAOYSA-N - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Linola sept 1 mg/g + 10 mg/g Wund-Gel Octenidine dihydrochloride (1 mg/g) + Phenoxyethanol (10 mg/g) Gel Topical Dr. August Wolff Gmb H & Co. Kg Arzneimittel 2015-03-23 Not applicable Austria Linola sept 1 mg/g + 20 mg/g Wund-Spray zur Anwendung auf der Haut, Lösung Octenidine dihydrochloride (1 mg/g) + Phenoxyethanol (20 mg/g) Spray Topical Dr. August Wolff Gmb H & Co. Kg Arzneimittel 2015-03-23 Not applicable Austria Octeniderm - Lösung zur Hautdesinfektion Octenidine dihydrochloride (0.1 g) + Isopropyl alcohol (45 g) + Propyl alcohol (30 g) Solution Topical Schulke & Mayr Gmb H 2002-02-18 Not applicable Austria Octenisept - Lösung zur Wund- und Schleimhautdesinfektion Octenidine dihydrochloride (0.1 %) + Phenoxyethanol (2 %) Solution Topical Schulke & Mayr Gmb H 1994-02-15 Not applicable Austria OCTENISEPT ÇÖZELTI, 1000 ML Octenidine dihydrochloride (0.1 g) + Phenoxyethanol (2 g) Solution Topical FARMAKİM İLAÇ KİMYA GIDA ÜRÜNLERİ ÜRETİM SAN.VE DIŞ TİC. A.Ş. 2020-08-14 Not applicable Turkey
Categories
- ATC Codes
- G01AX66 — Octenidine, combinations
- G01AX — Other antiinfectives and antiseptics
- G01A — ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
- G01 — GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
- G — GENITO URINARY SYSTEM AND SEX HORMONES
- A01AB — Antiinfectives and antiseptics for local oral treatment
- A01A — STOMATOLOGICAL PREPARATIONS
- A01 — STOMATOLOGICAL PREPARATIONS
- A — ALIMENTARY TRACT AND METABOLISM
- Drug Categories
- Alimentary Tract and Metabolism
- Anti-Infective Agents
- Anti-Infective Agents, Local
- Antiinfectives and Antiseptics for Local Oral Treatment
- Antiseptics and Disinfectants
- Dermatologicals
- Genito Urinary System and Sex Hormones
- Gynecological Antiinfectives and Antiseptics
- Quaternary Ammonium Compounds
- Stomatological Preparations
- Throat Preparations
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as dihydropyridines. These are compounds containing a dihydropyridine moiety, which is a semi-saturated pyridine derivative with two double bonds.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Pyridines and derivatives
- Sub Class
- Hydropyridines
- Direct Parent
- Dihydropyridines
- Alternative Parents
- Secondary ketimines / Heteroaromatic compounds / Azacyclic compounds / Organopnictogen compounds / Hydrocarbon derivatives
- Substituents
- Aromatic heteromonocyclic compound / Azacycle / Dihydropyridine / Heteroaromatic compound / Hydrocarbon derivative / Organic nitrogen compound / Organonitrogen compound / Organopnictogen compound / Secondary ketimine
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- OZE0372S5A
- CAS number
- 71251-02-0
- InChI Key
- ZVXNYZWXUADSRV-UHFFFAOYSA-N
- InChI
- InChI=1S/C36H62N4/c1-3-5-7-9-15-19-27-37-35-23-31-39(32-24-35)29-21-17-13-11-12-14-18-22-30-40-33-25-36(26-34-40)38-28-20-16-10-8-6-4-2/h23-26,31-34H,3-22,27-30H2,1-2H3
- IUPAC Name
- N-(1-{10-[4-(octylimino)-1,4-dihydropyridin-1-yl]decyl}-1,4-dihydropyridin-4-ylidene)octan-1-amine
- SMILES
- CCCCCCCCN=C1C=CN(CCCCCCCCCCN2C=CC(C=C2)=NCCCCCCCC)C=C1
References
- General References
- External Links
- PubChem Compound
- 51167
- PubChem Substance
- 347828836
- ChemSpider
- 46371
- 2119240
- ChEBI
- 135826
- ChEMBL
- CHEMBL1199480
- ZINC
- ZINC000008214632
- Wikipedia
- Octenidine_dihydrochloride
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Prevention Bacteremia / Bacterial Infections / Catheter-Associated Infections / Central Venous Catheterization 1 3 Completed Prevention Inhibition of Plaque Formation (by Gingivitis-Index ≤1.5) 2 2 Completed Prevention Pre-operative skin preparation 1 2 Completed Treatment Atopic Dermatitis 1 2 Completed Treatment Candidiasis 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Gel Topical Spray Topical Pastille 2.6 mg Solution Oral 1 mg/ml Solution Topical Solution Topical 0.1 % - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 2.6e-05 mg/mL ALOGPS logP 8.23 ALOGPS logP 11.06 Chemaxon logS -7.3 ALOGPS pKa (Strongest Basic) 10.89 Chemaxon Physiological Charge 2 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 31.2 Å2 Chemaxon Rotatable Bond Count 25 Chemaxon Refractivity 179.43 m3·mol-1 Chemaxon Polarizability 75.45 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 247.88316 predictedDeepCCS 1.0 (2019) [M+H]+ 250.55974 predictedDeepCCS 1.0 (2019) [M+Na]+ 257.7782 predictedDeepCCS 1.0 (2019)
Drug created at October 20, 2016 23:17 / Updated at June 08, 2021 11:32