Dihydropteroate synthase

BE0001974ProteinMycobacterium tuberculosisfolP1

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives. It is acted on by 1 drug in DrugBank.

Gene name
folP1
UniProtKB entry
P9WND1Swiss-Prot
Residues / weight
280 residues · 28,843 Da
Also known as
2.5.1.15 · DHPS · Dihydropteroate pyrophosphorylase

Resolves to

Protein
UniProtP9WND1UniProt nameDHPS1_MYCTU
Gene
NCBI Gene885831
Pharmacology
KEGGmtu:Rv3608c
Structure
PDB1EYE
Drugs

What you can answer from here — as of September 04, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Dihydropteroate synthase, and which indications are they being tested in?

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