Proline iminopeptidase

Details

Name
Proline iminopeptidase
Kind
protein
Synonyms
  • 3.4.11.5
  • PAP
  • PIP
  • Prolyl aminopeptidase
Gene Name
pip
UniProtKB Entry
O32449Swiss-Prot
Organism
Serratia marcescens
NCBI Taxonomy ID
615
Amino acid sequence
>lcl|BSEQ0016636|Proline iminopeptidase
MEQLRGLYPPLAAYDSGWLDTGDGHRIYWELSGNPNGKPAVFIHGGPGGGISPHHRQLFD
PERYKVLLFDQRGCGRSRPHASLDNNTTWHLVADIERLREMAGVEQWLVFGGSWGSTLAL
AYAQTHPERVSEMVLRGIFTLRKQRLHWYYQDGASRFFPEKWERVLSILSDDERKDVIAA
YRQRLTSADPQVQLEAAKLWSVWEGETVTLLPSRESASFGEDDFALAFARIENHYFTHLG
FLESDDQLLRNVPLIRHIPAVIVHGRYDMACQVQNAWDLAKAWPEAELHIVEGAGHSYDE
PGILHQLMIATDRFAGK
Number of residues
317
Molecular Weight
36083.36
Theoretical pI
6.23
GO Classification
Functions
aminopeptidase activity
Components
cytoplasm
General Function
Specifically catalyzes the removal of N-terminal proline residues from peptides.
Specific Function
aminopeptidase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0003926|954 bp
ATGGAACAATTACGAGGTTTGTACCCGCCGTTAGCGGCATACGACAGCGGTTGGCTGGAT
ACTGGGGATGGCCACCGGATCTACTGGGAGCTGAGCGGTAACCCGAACGGTAAACCGGCG
GTATTCATTCACGGCGGGCCGGGCGGCGGCATCTCCCCGCATCATCGTCAGCTGTTCGAT
CCCGAACGCTACAAGGTGCTGCTGTTCGATCAGCGCGGTTGCGGCCGCTCCCGTCCGCAT
GCCAGCCTGGACAACAACACCACCTGGCATTTGGTGGCCGATATCGAGCGGCTGCGCGAA
ATGGCCGGCGTCGAGCAGTGGCTGGTGTTCGGCGGTTCCTGGGGATCGACGCTGGCGCTC
GCCTATGCGCAGACCCACCCGGAGCGCGTCAGTGAAATGGTGCTGCGCGGCATCTTCACC
CTGCGCAAGCAGAGGCTGCATTGGTATTACCAGGACGGCGCTTCGCGCTTCTTCCCGGAA
AAATGGGAGCGCGTGCTGTCCATCCTCTCGGATGACGAGCGTAAAGACGTGATCGCCGCC
TACCGGCAGCGGCTGACCTCGGCCGATCCGCAGGTGCAGCTTGAAGCGGCCAAACTGTGG
AGCGTGTGGGAAGGGGAGACGGTCACGCTGCTGCCGAGCCGCGAATCCGCTTCGTTCGGC
GAGGATGATTTCGCGCTGGCGTTCGCCCGCATTGAAAACCACTACTTCACCCATCTGGGC
TTCCTGGAAAGCGACGACCAACTGCTGCGCAACGTGCCGCTGATCCGCCATATTCCGGCG
GTGATCGTCCACGGCCGCTATGACATGGCCTGCCAGGTGCAGAACGCCTGGGACCTGGCC
AAGGCCTGGCCGGAGGCGGAGCTGCATATCGTGGAAGGGGCGGGGCATTCGTATGATGAG
CCGGGCATTTTGCACCAGCTGATGATCGCCACCGACCGGTTTGCCGGCAAATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDO32449
UniProtKB Entry NamePIP_SERMA
GenBank Protein ID2605615
GenBank Gene IDD87897
PDB ID(s)1QTR, 1WM1, 1X2B, 1X2E
General References
  1. Kabashima T, Kitazono A, Kitano A, Ito K, Yoshimoto T: Prolyl aminopeptidase from Serratia marcescens: cloning of the enzyme gene and crystallization of the expressed enzyme. J Biochem. 1997 Sep;122(3):601-5. [Article]
  2. Ito K, Inoue T, Kabashima T, Kanada N, Huang HS, Ma X, Azmi N, Azab E, Yoshimoto T: Substrate recognition mechanism of prolyl aminopeptidase from Serratia marcescens. J Biochem. 2000 Oct;128(4):673-8. [Article]
  3. Yoshimoto T, Kabashima T, Uchikawa K, Inoue T, Tanaka N, Nakamura KT, Tsuru M, Ito K: Crystal structure of prolyl aminopeptidase from Serratia marcescens. J Biochem. 1999 Sep;126(3):559-65. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
2-Prolyl-5-Tert-Butyl-[1,3,4]OxadiazoleexperimentalunknowntargetDetails
(2S)-2-AMINO-1-(5-TERT-BUTYL-1,3,4-OXADIAZOL-2-YL)PROPAN-1-ONEexperimentalunknowntargetDetails
1-(5-TERT-BUTYL-1,3,4-OXADIAZOL-2-YL)-2-(METHYLAMINO)ETHANONEexperimentalunknowntargetDetails