Ribokinase
Details
- Name
- Ribokinase
- Kind
- protein
- Synonyms
- 2.7.1.15
- Gene Name
- rbsK
- UniProtKB Entry
- P0A9J6Swiss-Prot
- Organism
- Escherichia coli (strain K12)
- NCBI Taxonomy ID
- 83333
- Amino acid sequence
>lcl|BSEQ0011438|Ribokinase MQNAGSLVVLGSINADHILNLQSFPTPGETVTGNHYQVAFGGKGANQAVAAGRSGANIAF IACTGDDSIGESVRQQLATDNIDITPVSVIKGESTGVALIFVNGEGENVIGIHAGANAAL SPALVEAQRERIANASALLMQLESPLESVMAAAKIAHQNKTIVALNPAPARELPDELLAL VDIITPNETEAEKLTGIRVENDEDAAKAAQVLHEKGIRTVLITLGSRGVWASVNGEGQRV PGFRVQAVDTIAAGDTFNGALITALLEEKPLPEAIRFAHAAAAIAVTRKGAQPSVPWREE IDAFLDRQR
- Number of residues
- 309
- Molecular Weight
- 32290.19
- Theoretical pI
- 4.73
- GO Classification
- FunctionsATP binding / ribokinase activityProcessescarbohydrate phosphorylation / D-ribose catabolic processComponentscytosol
- General Function
- Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
- Specific Function
- ATP binding
- Pfam Domain Function
- PfkB (PF00294)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0011439|Ribokinase (rbsK) ATGCAAAACGCAGGCAGCCTCGTTGTTCTTGGCAGCATTAATGCTGACCACATTCTTAAT CTTCAATCTTTTCCTACTCCAGGCGAAACCGTAACCGGTAACCACTATCAGGTTGCATTT GGCGGCAAAGGCGCGAATCAGGCTGTGGCTGCTGGGCGTAGCGGTGCGAATATCGCGTTT ATTGCCTGTACGGGTGATGACAGCATTGGTGAGAGCGTTCGCCAGCAGCTCGCCACTGAT AACATTGATATTACTCCGGTCAGCGTGATCAAAGGCGAATCAACAGGTGTGGCGCTGATT TTTGTTAATGGCGAAGGTGAGAATGTCATCGGTATTCATGCCGGCGCTAATGCTGCCCTT TCCCCGGCGCTGGTGGAAGCGCAACGTGAGCGTATTGCCAACGCGTCAGCATTATTAATG CAGCTGGAATCACCACTCGAAAGTGTGATGGCAGCGGCGAAAATCGCCCATCAAAATAAG ACTATCGTTGCGCTTAACCCGGCTCCGGCTCGCGAACTTCCTGACGAACTGCTGGCGCTG GTGGACATTATTACGCCAAACGAAACGGAAGCAGAAAAGCTCACCGGTATTCGTGTTGAA AATGATGAAGATGCAGCGAAGGCGGCGCAGGTACTGCATGAAAAAGGTATCCGTACTGTA CTGATTACTTTAGGAAGTCGTGGTGTATGGGCTAGCGTGAATGGTGAAGGTCAGCGCGTT CCTGGATTCCGGGTGCAGGCTGTCGATACCATTGCTGCCGGAGATACCTTTAACGGTGCG TTAATCACGGCATTGCTGGAAGAAAAACCATTGCCAGAGGCGATTCGTTTTGCCCATGCT GCCGCTGCGATTGCCGTAACACGTAAAGGCGCACAACCTTCCGTACCGTGGCGTGAAGAG ATCGACGCATTTTTAGACAGGCAGAGGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0A9J6 UniProtKB Entry Name RBSK_ECOLI GenBank Gene ID M13169 PDB ID(s) 1GQT, 1RK2, 1RKA, 1RKD, 1RKS KEGG ID ecj:JW3731 NCBI Gene ID 948260 - General References
- Hope JN, Bell AW, Hermodson MA, Groarke JM: Ribokinase from Escherichia coli K12. Nucleotide sequence and overexpression of the rbsK gene and purification of ribokinase. J Biol Chem. 1986 Jun 15;261(17):7663-8. [Article]
- Burland V, Plunkett G 3rd, Daniels DL, Blattner FR: DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication. Genomics. 1993 Jun;16(3):551-61. [Article]
- Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
- Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
- Sigrell JA, Cameron AD, Jones TA, Mowbray SL: Purification, characterization, and crystallization of Escherichia coli ribokinase. Protein Sci. 1997 Nov;6(11):2474-6. [Article]
- Sigrell JA, Cameron AD, Jones TA, Mowbray SL: Structure of Escherichia coli ribokinase in complex with ribose and dinucleotide determined to 1.8 A resolution: insights into a new family of kinase structures. Structure. 1998 Feb 15;6(2):183-93. [Article]
- Sigrell JA, Cameron AD, Mowbray SL: Induced fit on sugar binding activates ribokinase. J Mol Biol. 1999 Jul 30;290(5):1009-18. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details alpha-D-arabinofuranose experimental, investigational unknown target Details Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate experimental unknown target Details Tetrafluoroaluminate Ion experimental unknown target Details