Soluble cytochrome b562

Details

Name
Soluble cytochrome b562
Kind
protein
Synonyms
  • Cytochrome b-562
Gene Name
cybC
UniProtKB Entry
P0ABE7Swiss-Prot
Organism
Escherichia coli
NCBI Taxonomy ID
562
Amino acid sequence
>lcl|BSEQ0003956|Soluble cytochrome b562
MRKSLLAILAVSSLVFSSASFAADLEDNMETLNDNLKVIEKADNAAQVKDALTKMRAAAL
DAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTR
NAYHQKYR
Number of residues
128
Molecular Weight
14060.815
Theoretical pI
6.54
GO Classification
Functions
electron carrier activity / heme binding / iron ion binding
Processes
electron transport chain
Components
periplasmic space
General Function
Electron-transport protein of unknown function.
Specific Function
electron transfer activity
Pfam Domain Function
Signal Regions
1-22
Transmembrane Regions
Not Available
Cellular Location
Periplasm
Gene sequence
>lcl|BSEQ0003955|387 bp
ATGCGTAAAAGCCTGTTAGCTATTCTTGCAGTCTCCTCGTTGGTATTCAGTTCTGCGTCG
TTTGCCGCTGATCTTGAAGACAATATGGAAACCCTCAACGACAATTTAAAAGTGATCGAA
AAAGCGGATAACGCGGCGCAAGTCAAAGACGCGTTAACGAAGATGCGCGCCGCAGCCCTG
GATGCGCAAAAAGCAACGCCGCCGAAGCTCGAAGATAAATCACCGGACAGCCCGGAAATG
AAAGATTTCCGCCACGGTTTCGACATTCTGGTCGGTCAGATTGACGACGCGCTGAAGCTG
GCAAATGAAGGTAAAGTAAAAGAAGCGCAGGCTGCTGCAGAGCAACTGAAAACGACCCGC
AACGCCTATCACCAGAAGTATCGTTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP0ABE7
UniProtKB Entry NameC562_ECOLX
GenBank Protein ID241593
GenBank Gene IDS74736
PDB ID(s)1APC, 1LM3, 1M6T, 1QPU, 1QQ3, 256B, 2BC5, 2QLA, 3C62, 3C63, 3DE8, 3DE9, 3FOO, 3FOP, 3HNI, 3HNJ, 3HNK, 3HNL, 3IQ5, 3IQ6, 3L1M, 3M15, 3M4B, 3M4C, 3M79, 3NMI, 3NMJ, 3NMK, 3TOL, 3TOM, 3U8P, 4EA3, 4EIY, 4IAQ, 4IAR, 4IB4, 4JE9, 4JEA, 4JEB, 4JKV, 4L6R, 4N6H, 4NC3, 4NTJ, 4O9R, 4OR2, 4PXZ, 4PY0, 4QIM, 4QIN, 4RWA, 4RWD, 4U9D, 4U9E, 4YAY, 4Z34, 4Z35, 4Z36, 4ZUD, 5AWI
General References
  1. Nikkila H, Gennis RB, Sligar SG: Cloning and expression of the gene encoding the soluble cytochrome b562 of Escherichia coli. Eur J Biochem. 1991 Dec 5;202(2):309-13. [Article]
  2. Trower MK: PCR cloning, sequence analysis and expression of the cybC genes encoding soluble cytochrome b-562 from Escherichia coli B strain OP7 and K strain NM522. Biochim Biophys Acta. 1993 Jun 10;1143(1):109-11. [Article]
  3. Itagaki E, Hager LP: The amino acid sequence of cytochrome b562 of Escherichia coli. Biochem Biophys Res Commun. 1968 Sep 30;32(6):1013-9. [Article]
  4. Mathews FS, Bethge PH, Czerwinski EW: The structure of cytochrome b562 from Escherichia coli at 2.5 A resolution. J Biol Chem. 1979 Mar 10;254(5):1699-706. [Article]
  5. Lederer F, Glatigny A, Bethge PH, Bellamy HD, Matthew FS: Improvement of the 2.5 A resolution model of cytochrome b562 by redetermining the primary structure and using molecular graphics. J Mol Biol. 1981 Jun 5;148(4):427-48. [Article]
  6. Hamada K, Bethge PH, Mathews FS: Refined structure of cytochrome b562 from Escherichia coli at 1.4 A resolution. J Mol Biol. 1995 Apr 14;247(5):947-62. [Article]
  7. Springs SL, Bass SE, Bowman G, Nodelman I, Schutt CE, McLendon GL: A multigeneration analysis of cytochrome b(562) redox variants: evolutionary strategies for modulating redox potential revealed using a library approach. Biochemistry. 2002 Apr 2;41(13):4321-8. [Article]
  8. Arnesano F, Banci L, Bertini I, Faraone-Mennella J, Rosato A, Barker PD, Fersht AR: The solution structure of oxidized Escherichia coli cytochrome b562. Biochemistry. 1999 Jul 6;38(27):8657-70. [Article]
  9. Assfalg M, Banci L, Bertini I, Ciofi-Baffoni S, Barker PD: (15)N backbone dynamics of ferricytochrome b(562): comparison with the reduced protein and the R98C variant. Biochemistry. 2001 Oct 30;40(43):12761-71. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Hybrid Between B and C Type Hemes (Protoporphyrin Ixcontaining Fe)experimentalunknowntargetDetails
N-1,10-phenanthrolin-5-ylacetamideexperimentalunknowntargetDetails