Pyruvate dehydrogenase E1 component

BE0002003ProteinEscherichia coli (strain K12)aceE

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It is acted on by 2 drugs in DrugBank.

Gene name
aceE
UniProtKB entry
P0AFG8Swiss-Prot
Residues / weight
887 residues · 99,668 Da
Also known as
1.2.4.1 · PDH E1 component

Resolves to

Protein
UniProtP0AFG8UniProt nameODP1_ECOLI
Gene
NCBI Gene944834
Pharmacology
KEGGecj:JW0110
Structure
PDB1L8APDB1RP7PDB2G25
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Pyruvate dehydrogenase E1 component, how selective are they, and which programs against it are still in active trials?

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