Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

BE0002006ProteinEscherichia coli (strain K12)fabI

Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). It is acted on by 10 drugs in DrugBank.

Gene name
fabI
UniProtKB entry
P0AEK4Swiss-Prot
Cellular location
Cell inner membrane; peripheral membrane protein
Residues / weight
262 residues · 27,864 Da
Also known as
1.3.1.9 · ENR · envM · NADH-dependent enoyl-ACP reductase

Resolves to

Protein
UniProtP0AEK4UniProt nameFABI_ECOLI
Gene
NCBI Gene945870GenBank587106
Pharmacology
KEGGecj:JW1281
Structure
PDB1C14PDB1D8APDB1DFG
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
9GO termsFunction, process and component, as structured annotations
Sign in
34+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Enoyl-[acyl-carrier-protein] reductase [NADH] FabI, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In