Streptopain

BE0002024ProteinStreptococcus pyogenesspeB

Cysteine protease that acts as a key streptococcal virulence factor by cleaving host proteins involved in immune response (PubMed:10429198, PubMed:11553627, PubMed:1987034, PubMed:22645124, PubMed:8675287, PubMed:9169486, PubMed:9864206). It is acted on by 2 drugs in DrugBank.

Gene name
speB
UniProtKB entry
P0C0J0Swiss-Prot
Cellular location
Secreted
Residues / weight
398 residues · 43,174 Da
Also known as
3.4.22.10 · Exotoxin type B · Group A streptococcal cysteine protease · SPE B · SPP

Resolves to

Protein
UniProtP0C0J0UniProt nameSPEB_STRPY
Gene
GenBank153819
Structure
PDB1DKIPDB1PVJPDB2UZJ
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Streptopain, how selective are they, and which programs against it are still in active trials?

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