Sodium channel protein type 3 subunit alpha

BE0002082ProteinHumansSCN3A

Pore-forming subunit of Nav1.3, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. It is acted on by 7 drugs in DrugBank.

Gene name
SCN3A
UniProtKB entry
Q9NY46Swiss-Prot
Cellular location
Cell membrane
Residues / weight
2,000 residues · 226,292 Da
Also known as
KIAA1356 · NAC3 · Sodium channel protein brain III subunit alpha · Sodium channel protein type III subunit alpha · Voltage-gated sodium channel subtype III

Resolves to

Protein
UniProtQ9NY46UniProt nameSCN3A_HUMAN
Gene
HGNCHGNC:10590NCBI Gene6328GenBank7414320GeneCardsSCN3A
Pharmacology
IUPHAR/GtoPdb580KEGGhsa:6328
Structure
PDB7W77PDB7W7F
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium channel protein type 3 subunit alpha, how selective are they, and which programs against it are still in active trials?

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