Tetrodotoxin

DB05232InvestigationalSmall molecule

An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order tetraodontiformes, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.... Tetrodotoxin is being investigated by Wex Pharmaceuticals for the treatment of chronic and breakthrough pain in advanced cancer patients as well as for the treatment of opioid dependence.

Mechanism: Tetrodotoxin binds to site 1 of the fast voltage-gated sodium channel located at the extracellular pore opening. The binding of any molecules to this site will temporarily disable the function of the ion channel. Saxitoxin and several of the conotoxins also bind the same site.
Curator reviewed
Primary indication: For the treatment of chronic and breakthrough pain in advanced cancer patients as well as for the treatment of opioid dependence.Curator reviewed
Formula / weight: C₁₁H₁₇N₃O₈ · 319.268 g/mol (avg)

Resolves to

Compound

UNII3KUM2721U9CAS4368-28-9ChEBI9506PubChem21733122KEGGC11692

Structure

InChIKeySLBCPBUVHCASIJ-UFHSVNPDSA-OSMILES[H][C@]12OC3([O-])OC(C4C(O)[NH+]=C(N)NC4(C1O)[C@@H]3O)C2(O)CO

Targets

Q14524SCN5AP35498SCN1AQ99250SCN2AQ9NY46SCN3AQ9UQD0SCN8A

What you can answer from here — as of January 29, 2025

5Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1,625Drug interactionsStructured to mechanism, not free text

5Clinical trialsPhase, status and sponsor resolved per trial

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with Tetrodotoxin, and which of those have an active Phase 3 trial?

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