Sodium channel protein type 8 subunit alpha

BE0002084ProteinHumansSCN8A

Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient (PubMed:24874546, PubMed:25239001, PubMed:25725044,... It is acted on by 4 drugs in DrugBank.

Gene name
SCN8A
UniProtKB entry
Q9UQD0Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,980 residues · 225,278 Da
Also known as
MED · Sodium channel protein type VIII subunit alpha · Voltage-gated sodium channel subunit alpha Nav1.6

Resolves to

Protein
UniProtQ9UQD0UniProt nameSCN8A_HUMAN
Gene
HGNCHGNC:10596NCBI Gene6334GenBank4321647GeneCardsSCN8A
Pharmacology
IUPHAR/GtoPdb583KEGGhsa:6334
Structure
PDB8FHDPDB8GZ1PDB8GZ2
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
8GO termsFunction, process and component, as structured annotations
Sign in
4Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
18+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Sodium channel protein type 8 subunit alpha, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In