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Zandatrigine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

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Identification

Generic Name
Zandatrigine
DrugBank Accession Number
DB19051
Background

Zandatrigine is under investigation in clinical trial NCT05226780 (Extension Study to Evaluate How Safe and Tolerable NBI-921352 Is as an Adjunctive Therapy for Participants With SCN8A-DEE).

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 460.59
Monoisotopic: 460.140296572
Chemical Formula
C22H25FN4O2S2
Synonyms
  • Benzenesulfonamide, 2-fluoro-5-methyl-4-(methyl((3s)-1-(phenylmethyl)-3-pyrrolidinyl)amino)-n-4-thiazolyl-
External IDs
  • NBI 921352
  • NBI-921352
  • XEN 901
  • XEN-901
  • XEN901
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
SV2WPA4R4J
CAS number
2154406-04-7
InChI Key
UCSHINHOAVARGQ-SFHVURJKSA-N
InChI
InChI=1S/C22H25FN4O2S2/c1-16-10-21(31(28,29)25-22-14-30-15-24-22)19(23)11-20(16)26(2)18-8-9-27(13-18)12-17-6-4-3-5-7-17/h3-7,10-11,14-15,18,25H,8-9,12-13H2,1-2H3/t18-/m0/s1
IUPAC Name
SMILES
CN([C@H]1CCN(CC2=CC=CC=C2)C1)C1=CC(F)=C(C=C1C)S(=O)(=O)NC1=CSC=N1

References

General References
Not Available
ChemSpider
115285080
BindingDB
470680
ChEMBL
CHEMBL4650313

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
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2CompletedTreatmentPartial-Onset Seizures1somestatusstop reasonjust information to hide
2Enrolling by InvitationTreatmentSCN8A Developmental and Epileptic Encephalopathy Syndrome1somestatusstop reasonjust information to hide
2RecruitingTreatmentSCN8A Developmental and Epileptic Encephalopathy Syndrome1somestatusstop reasonjust information to hide
2TerminatedTreatmentPartial-Onset Seizures1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at July 03, 2024 13:17 / Updated at July 04, 2024 03:36