Dihydropteroate synthase

BE0002086ProteinMycobacterium leprae (strain TN)folP1

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate, the immediate precursor of folate derivatives. It is acted on by 2 drugs in DrugBank.

Gene name
folP1
UniProtKB entry
P0C0X1Swiss-Prot
Residues / weight
284 residues · 29,447 Da
Also known as
2.5.1.15 · DHPS · Dihydropteroate pyrophosphorylase · folP

Resolves to

Protein
UniProtP0C0X1UniProt nameDHPS1_MYCLE
Gene
NCBI Gene908646GenBank5832717
Pharmacology
KEGGmle:ML0224
Drugs

What you can answer from here — as of September 04, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dihydropteroate synthase, how selective are they, and which programs against it are still in active trials?

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