Sulfoxone

DB01145ApprovedSmall molecule

Sulfoxone is a water-soluble sulfone used as an antileprosy drug. It has been used with limited success in the treatment of dermatitis herpetiformis.

Mechanism: Sulfoxone is a competitive inhibitor of bacterial enzyme dihydropteroate synthetase. The normal substrate for the enzyme, para-aminobenzoic acid (PABA) cannot bind as usual. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Curator reviewed
Primary indication: For the treatment of leprosy and dermatitis herpetiformisCurator reviewed
Formula / weight: C₁₄H₁₆N₂O₆S₃ · 404.482 g/mol (avg)
Also known as: Aldesulfone · Aldesulphone

Resolves to

Compound

Clinical / RWD

Structure

InChIKeyNEDPPCHNEOMTJV-UHFFFAOYSA-NSMILESOS(=O)CNC1=CC=C(C=C1)S(=O)(=O)C1=CC=C(NCS(O)=O)C=C1

Targets

What you can answer from here — as of September 13, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1ATC codeIncluding every combination product, plus 5 drug categories

7+ReferencesStructured and connected to the statements they support

Which drugs share a target with Sulfoxone, and which of those have an active Phase 3 trial?

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