Complement C1r subcomponent

BE0002093ProteinHumansC1R

Serine protease component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that... It is acted on by 10 drugs in DrugBank.

Gene name
C1R
UniProtKB entry
P00736Swiss-Prot
Cellular location
Secreted
Residues / weight
705 residues · 80,118 Da
Also known as
3.4.21.41 · Complement component 1 subcomponent r

Resolves to

Protein
UniProtP00736UniProt nameC1R_HUMAN
Gene
HGNCHGNC:1246NCBI Gene715GenBank29539GeneCardsC1R
Pharmacology
IUPHAR/GtoPdb2334KEGGhsa:715
Structure
PDB1APQPDB1GPZPDB1MD7
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Complement C1r subcomponent, how selective are they, and which programs against it are still in active trials?

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