Prolow-density lipoprotein receptor-related protein 1

BE0002110ProteinHumansLRP1

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). It is acted on by 10 drugs in DrugBank.

Gene name
LRP1
UniProtKB entry
Q07954Swiss-Prot
Cellular location
Cell membrane
Residues / weight
4,544 residues · 504,602 Da
Also known as
A2MR · Alpha-2-macroglobulin receptor · APOER · Apolipoprotein E receptor · APR

Resolves to

Protein
UniProtQ07954UniProt nameLRP1_HUMAN
Gene
HGNCHGNC:6692NCBI Gene4035GenBank34339GeneCardsLRP1
Pharmacology
KEGGhsa:4035
Structure
PDB1CR8PDB1D2LPDB1J8E
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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41GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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41+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Prolow-density lipoprotein receptor-related protein 1, how selective are they, and which programs against it are still in active trials?

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