Phospholipase D2

BE0002179ProteinHumansPLD2

Function as phospholipase selective for phosphatidylcholine (PubMed:9582313). It is acted on by 4 drugs in DrugBank.

Gene name
PLD2
UniProtKB entry
O14939Swiss-Prot
Cellular location
Cell membrane
Residues / weight
933 residues · 105,986 Da
Also known as
3.1.4.4 · Choline phosphatase 2 · hPLD2 · Phosphatidylcholine-hydrolyzing phospholipase D2 · PLD 2

Resolves to

Protein
UniProtO14939UniProt namePLD2_HUMAN
Gene
HGNCHGNC:9068NCBI Gene5338GenBank2645858GeneCardsPLD2
Pharmacology
IUPHAR/GtoPdb1434KEGGhsa:5338
Structure
PDB6OHMPDB6OHOPDB6OHP
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phospholipase D2, how selective are they, and which programs against it are still in active trials?

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