Chloroform
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Chloroform
- DrugBank Accession Number
- DB11387
- Background
Chloroform is an organic small molecule, member of the family of the chloromethanes that presents a formula of CHCl3. It is a colorless, sweet-smelling, dense liquid that is produced on a large scale as a precursor to PTFE and refrigerants, but the latter application is declining. Chloroform is part of the FDA drug products withdrawn or removed from the market for reasons of safety or effectiveness.23
- Type
- Small Molecule
- Groups
- Approved, Vet approved, Withdrawn
- Structure
- Weight
- Average: 119.378
Monoisotopic: 117.914383153 - Chemical Formula
- CHCl3
- Synonyms
- 1,1,1-trichloromethane
- CHCl3
- Chloroforme
- chloroformium pro narcosi
- Trichlormethan
- Trichloromethane
- trichlorométhane
- External IDs
- NSC-77361
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAlfentanil The therapeutic efficacy of Chloroform can be increased when used in combination with Alfentanil. Anileridine The therapeutic efficacy of Chloroform can be increased when used in combination with Anileridine. Clonidine The therapeutic efficacy of Chloroform can be increased when used in combination with Clonidine. Desflurane The therapeutic efficacy of Chloroform can be increased when used in combination with Desflurane. Dexmedetomidine The therapeutic efficacy of Chloroform can be increased when used in combination with Dexmedetomidine. - Food Interactions
- Not Available
Categories
- ATC Codes
- N01AB02 — Chloroform
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as trihalomethanes. These are organic compounds in which exactly three of the four hydrogen atoms of methane (CH4) are replaced by halogen atoms.
- Kingdom
- Organic compounds
- Super Class
- Organohalogen compounds
- Class
- Alkyl halides
- Sub Class
- Halomethanes
- Direct Parent
- Trihalomethanes
- Alternative Parents
- Organochlorides / Hydrocarbon derivatives / Alkyl chlorides
- Substituents
- Aliphatic acyclic compound / Alkyl chloride / Hydrocarbon derivative / Organochloride / Trihalomethane
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- one-carbon compound, chloromethanes (CHEBI:35255) / a small molecule (CPD-843)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 7V31YC746X
- CAS number
- 67-66-3
- InChI Key
- HEDRZPFGACZZDS-UHFFFAOYSA-N
- InChI
- InChI=1S/CHCl3/c2-1(3)4/h1H
- IUPAC Name
- trichloromethane
- SMILES
- ClC(Cl)Cl
References
- General References
- FEATHERSTONE HW: Chloroform. Anesthesiology. 1947 Jul;8(4):362-71. [Article]
- PAYNE JP: Chloroform. Med Illus. 1955 Oct;9(10):627-30. [Article]
- Authors unspecified: Chloroform. Rep Carcinog. 2002;10:54-6. [Article]
- Davison MH: Chloroform. Br J Anaesth. 1965 Sep;37(9):655-60. [Article]
- Authors unspecified: Chloroform. Rep Carcinog. 2004;11:III54-6. [Article]
- Authors unspecified: Chloroform. IARC Monogr Eval Carcinog Risks Hum. 1999;73:131-82. [Article]
- Authors unspecified: Chloroform. Rep Carcinog. 2011;12:97-100. [Article]
- Authors unspecified: Chloroform. IARC Monogr Eval Carcinog Risk Chem Hum. 1979 Oct;20:401-27. [Article]
- Lister J: Chloroform Accidents. Br Med J. 1871 Jul 29;2(552):117-9. [Article]
- Prichard A: Chloroform Accidents. Br Med J. 1873 Feb 22;1(634):194-6. [Article]
- Firth NL, Ross DA, Thonney ML: Comparison of ether and chloroform for Soxhlet extraction of freeze-dried animal tissues. J Assoc Off Anal Chem. 1985 Nov-Dec;68(6):1228-31. [Article]
- Exner T, Papadopoulos G, Sahman N, Koutts J: Solvent extraction of test plasmas for improved recovery of lupus anticoagulant activity. Thromb Haemost. 1990 Aug 13;64(1):121-3. [Article]
- Barker JL, Gainer H: Pentobarbital: selective depression of excitatory postsynaptic potentials. Science. 1973 Nov 16;182(4113):720-2. [Article]
- Huo Y, Guo C, Zhang QY, Chen WS, Zheng HC, Rahman K, Qin LP: Antinociceptive activity and chemical composition of constituents from Caragana microphylla seeds. Phytomedicine. 2007 Feb;14(2-3):143-6. Epub 2006 May 16. [Article]
- Svetaz L, Tapia A, Lopez SN, Furlan RL, Petenatti E, Pioli R, Schmeda-Hirschmann G, Zacchino SA: Antifungal chalcones and new caffeic acid esters from Zuccagnia punctata acting against soybean infecting fungi. J Agric Food Chem. 2004 Jun 2;52(11):3297-300. [Article]
- Schmidt CW: Chloroform: An EPA test case. Environ Health Perspect. 1999 Jul;107(7):A358-60. [Article]
- Vajrabhaya LO, Suwannawong SK, Kamolroongwarakul R, Pewklieng L: Cytotoxicity evaluation of gutta-percha solvents: Chloroform and GP-Solvent (limonene). Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Dec;98(6):756-9. [Article]
- Lionte C: Lethal complications after poisoning with chloroform--case report and literature review. Hum Exp Toxicol. 2010 Jul;29(7):615-22. doi: 10.1177/0960327109357142. Epub 2010 Jan 5. [Article]
- Cappelletti M, Frascari D, Zannoni D, Fedi S: Microbial degradation of chloroform. Appl Microbiol Biotechnol. 2012 Dec;96(6):1395-409. doi: 10.1007/s00253-012-4494-1. Epub 2012 Oct 24. [Article]
- Yang M, Wang L, Xie G, Liu Y: Effects of intermediate metabolites of 37 xenobiotics on the catalytic activities of reconstituted cytochrome P-450IIB1 and P-450IA1 enzyme systems. Biomed Environ Sci. 1993 Mar;6(1):8-26. [Article]
- Sprankle CS, Larson JL, Goldsworthy SM, Butterworth BE: Levels of myc, fos, Ha-ras, met and hepatocyte growth factor mRNA during regenerative cell proliferation in female mouse liver and male rat kidney after a cytotoxic dose of chloroform. Cancer Lett. 1996 Mar 19;101(1):97-106. [Article]
- Yannai, Shmuel (2003). Dictionary of Food Compounds with : Additives, Flavors, and Ingredients. CRC Press LLC. [ISBN:1584884169]
- Code of Federal Regulations 216.24: Drug products withdrawn or removed from the market for reasons of safety or effectiveness. [Link]
- External Links
- Human Metabolome Database
- HMDB0029596
- KEGG Compound
- C13827
- ChemSpider
- 5977
- 1362698
- ChEBI
- 35255
- ChEMBL
- CHEMBL44618
- ZINC
- ZINC000008214524
- PDBe Ligand
- MCH
- Wikipedia
- Chloroform
Clinical Trials
- Clinical Trials
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Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 6.95 mg/mL ALOGPS logP 1.67 ALOGPS logP 1.83 Chemaxon logS -1.2 ALOGPS Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 21.37 m3·mol-1 Chemaxon Polarizability 8.52 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 80.9267882 predictedDarkChem Lite v0.1.0 [M-H]- 123.81459 predictedDeepCCS 1.0 (2019) [M+H]+ 125.7341 predictedDeepCCS 1.0 (2019) [M+Na]+ 134.15361 predictedDeepCCS 1.0 (2019)
Drug created at February 25, 2016 18:19 / Updated at November 18, 2022 07:07