Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3

BE0002195ProteinHumansPLOD3

Multifunctional enzyme that catalyzes a series of essential post-translational modifications on Lys residues in procollagen (PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812). It is acted on by 2 drugs in DrugBank.

Gene name
PLOD3
UniProtKB entry
O60568Swiss-Prot
Cellular location
Rough endoplasmic reticulum
Residues / weight
738 residues · 84,785 Da

Resolves to

Protein
UniProtO60568UniProt namePLOD3_HUMAN
Gene
HGNCHGNC:9083NCBI Gene8985GenBank3153235GeneCardsPLOD3
Pharmacology
KEGGhsa:8985
Structure
PDB6FXKPDB6FXMPDB6FXR
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3, how selective are they, and which programs against it are still in active trials?

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