Gamma-butyrobetaine dioxygenase

BE0002197ProteinHumansBBOX1

Catalyzes the formation of L-carnitine from gamma-butyrobetaine. It is acted on by 2 drugs in DrugBank.

Gene name
BBOX1
UniProtKB entry
O75936Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
387 residues · 44,715 Da
Also known as
1.14.11.1 · BBH · BBOX · Gamma-BBH · Gamma-butyrobetaine hydroxylase

Resolves to

Protein
UniProtO75936UniProt nameBODG_HUMAN
Gene
HGNCHGNC:964NCBI Gene8424GenBank3746805GeneCardsBBOX1
Pharmacology
KEGGhsa:8424
Structure
PDB3MS5PDB3N6WPDB3O2G
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-butyrobetaine dioxygenase, how selective are they, and which programs against it are still in active trials?

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